News Column

New Findings from Harvard University Update Understanding of General Science

February 21, 2014

By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Science. According to news reporting originating in Boston, Massachusetts, by NewsRx journalists, research stated, "Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases, including cancer and atherosclerosis. However, the exact mechanism by which nanomedicines accumulate at targeted sites remains a topic of investigation, especially in the context of atherosclerotic disease."

The news reporters obtained a quote from the research from Harvard University, "Models to accurately predict transvascular permeation of nanomedicines are needed to aid in design optimization. Here we show that an endothelialized microchip with controllable permeability can be used to probe nanoparticle translocation across an endothelial cell layer. To validate our in vitro model, we studied nanoparticle translocation in an in vivo rabbit model of atherosclerosis using a variety of preclinical and clinical imaging methods. Our results reveal that the translocation of lipid-polymer hybrid nanoparticles across the atherosclerotic endothelium is dependent on microvascular permeability."

According to the news reporters, the research concluded: "These results were mimicked with our microfluidic chip, demonstrating the potential utility of the model system."

For more information on this research see: Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America, 2014;111(3):1078-1083. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences -; Proceedings of the National Academy of Sciences of the United States of America -

Our news correspondents report that additional information may be obtained by contacting Y. Kim, Harvard University, Sch Med, Brigham & Women's Hospital, Dept. of Anesthesiol, Boston, MA 02215, United States. Additional authors for this research include M.E. Lobatto, T. Kawahara, B.L. Chung, A.J. Mieszawska, B.L. Sanchez-Gaytan, F. Fay, M.L. Senders, C. Calcagno, J. Becraft, M.T. Saung, R.E. Gordon, E.S.G. Stroes, M.M. Ma, O.C. Farokhzad, Z.A. Fayad, W.J.M. Mulder and R. Langer (see also Science).

Keywords for this news article include: Boston, Science, Massachusetts, United States, North and Central America

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Source: Science Letter

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