Immunotherapy, a treatment that uses the body's own immune system to help fight infection and disease, received significant attention over the past year and was named Science magazine's 2013 Breakthrough of the Year. Given the heightened attention, cancer immunotherapy, also known as immuno-oncology, will be a featured topic at the preeminent clinical oncology conference, the
Dr. Traber was joined on the panel by several leaders in immunotherapy including
The panel reviewed the general field of immunotherapy, the recent successes and potential future directions. The launch of Yervoy® (ipilimumab) for the treatment of advanced melanoma and the clinical trial successes of anti-PD1 and anti-PD1-L has generated great interest for the potential of durable clinical responses. However, there is room for improvement as only 10 to 20 percent of patients respond to Yervoy therapy. The panel discussed the many potential targets that are under investigation including positive and negative T-cell agents, tumor vaccines, cellular therapies, adoptive immune therapies and therapies targeting the tumor microenvironment. It was broadly acknowledged that combination therapies will be the ultimate solution for increasing the percentage of responders in various tumor types.
Regarding targeting the tumor microenvironment, Dr. Traber noted the importance of galectin-3, which is secreted by the majority of cancers and its effects on the induction of immune responses to the tumor as well as the suppressive effect of galectin-3 on the activity of CD8+ T-cells that inhibits tumor killing activity. Dr. Traber reviewed preclinical data, generated by Dr.
As a result of these preclinical studies using a galectin-3 inhibitor,
Yervoy® is a registered trademark of Bristol-Myers Squibb Company.
Forward Looking Statements
This press release contains, in addition to historical information, forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements relate to future events or future financial performance, and use words such as "may," "estimate," "could," "expect" and others. They are based on our current expectations and are subject to factors and uncertainties which could cause actual results to differ materially from those described in the statements. These statements include those regarding potential developments in immunotherapy and certain treatment and therapy options and related clinical studies. Factors that could cause our actual performance to differ materially from those discussed in the forward-looking statements include, among others, that plans, expectations and goals regarding any potential developments in immunotherapy and any related treatments and studies may not materialize, and any preclinical data and potential therapeutic uses and benefits of our drugs and any future pre-clinical or clinical studies are subject to factors beyond our control. Future clinical studies may not begin or produce positive results in a timely fashion, if at all, and could prove time consuming and costly. Plans regarding development, approval and marketing of any of our drugs are subject to change at any time based on the changing needs of our company as determined by management and regulatory agencies. Regardless of the results of current or future studies, we may be unsuccessful in developing partnerships with other companies or obtaining capital that would allow us to further develop and/or fund any studies or trials. To date, we have incurred operating losses since our inception, and our ability to successfully develop and market drugs may be impacted by our ability to manage costs and finance our continuing operations. For a discussion of additional factors impacting our business, see our Annual Report on Form 10-K for the year ended
Galectin Therapeutics Inc. Peter G. Traber, MD, 678-620-3186 President, CEO, & CMO firstname.lastname@example.org