News Column

Study Results from Virginia Commonwealth University Broaden Understanding of Proinsulin

February 19, 2014



By a News Reporter-Staff News Editor at Biotech Week -- New research on Peptide Proteins is the subject of a report. According to news originating from Richmond, Virginia, by NewsRx editors, the research stated, "The development of Exubera() (inhaled insulin) has paved the way for consideration of future inhaled biotherapeutic products for systemic delivery. This route of drug delivery favors highly potent small peptides without self-association and large proteins resistant to enzymatic degradation for high bioavailability, while likely resulting in transient therapeutic effects."

Our news journalists obtained a quote from the research from Virginia Commonwealth University, "Improved therapeutic benefits with a needle-free delivery, such as inhaled insulin, are also rational pursuits. Molecules and their formulations must be carefully chosen and designed to optimize the rates of lung absorption and nonabsorptive loss. Novel molecular or formulation approaches, for example, Technosphere(), Fc-/scFv-fusion protein, PEGylation, polymeric or lipid-based micro/nanoparticles and liposomes, offer opportunities to improve lung absorption and therapeutic duration of some biotherapeutics."

According to the news editors, the research concluded: "Critical assessments are now essential as to their therapeutic benefits, safety, patient acceptance and market competition, as carried out for Exubera."

For more information on this research see: Systemic delivery of biotherapeutics through the lung: opportunities and challenges for improved lung absorption. Therapeutic Delivery, 2013;4(12):1511-25 (see also Peptide Proteins).

The news correspondents report that additional information may be obtained from M. Sakagami, Dept. of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 North, 12th Street, PO Box 980533, Richmond, VA, 23298, United States.

Keywords for this news article include: Therapy, Richmond, Virginia, United States, Peptide Proteins, North and Central America.

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Source: Biotech Week


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