By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Lipid Research are discussed in a new report. According to news reporting out of Lisbon, Portugal, by NewsRx editors, research stated, "Ceramide (Cer) is involved in the regulation of several cellular processes by mechanisms that depend on Cer-induced changes on membrane biophysical properties. Accumulating evidence shows that Cers with different N-acyl chain composition differentially impact cell physiology, which may in part be due to specific alterations in membrane biophysical properties."
Our news journalists obtained a quote from the research from the University of Lisbon, "We now address how the sphingolipid (SL) N-acyl chain affects membrane properties in cultured human embryonic kidney cells by overexpressing different Cer synthases (CerSs). Our results show an increase in the order of cellular membranes in CerS2-transfected cells caused by the enrichment in very long acyl chain SLs. Formation of Cer upon treatment of cells with bacterial sphingomyelinase promoted sequential changes in the properties of the membranes: after an initial increase in the order of the fluid plasma membrane, reorganization into domains with gel-like properties whose characteristics are dependent on the acyl chain structure of the Cer was observed. Moreover, the extent of alterations of membrane properties correlates with the amount of Cer formed."
According to the news editors, the research concluded: "These data reinforce the significance of Cer-induced changes on membrane biophysical properties as a likely molecular mechanism by which different acyl chain Cers exert their specific biological actions."
For more information on this research see: Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain. Journal of Lipid Research, 2014;55(1):53-61. Journal of Lipid Research can be contacted at: Amer Soc Biochemistry Molecular Biology Inc, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA. (American Society for Biochemistry and Molecular Biology - www.asbmb.org; Journal of Lipid Research - www.jlr.org/)
Our news journalists report that additional information may be obtained by contacting S.N. Pinto, Centro de Quimica-Fisica Molecular and Institute of Nanoscience and Nanotechnology, Instituto Superior Tecnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal. Additional authors for this research include E.L. Laviad, J. Stiban, S.L. Kelly, A.H. Merrill, M. Prieto, A.H. Futerman and L.C Silva (see also Lipid Research).
Publisher contact information for the Journal of Lipid Research is: Amer Soc Biochemistry Molecular Biology Inc, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA.
Keywords for this news article include: Lisbon, Europe, Portugal, Lipid Research.
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