By a News Reporter-Staff News Editor at Drug Week -- Research findings on Nanoparticles are discussed in a new report. According to news originating from Munster, Germany, by NewsRx correspondents, research stated, "Nanoparticles composed of poly(DL-lactide-co-glycolide) (PLGA) represent promising colloidal drug carriers for improved drug targeting. Although most research activities are focused on intravenous application of these carriers the peroral administration is described to improve bioavailability of poorly soluble drugs."
Our news journalists obtained a quote from the research from the University of Munster, "Based on these insights the manuscript describes a model tablet formulation for PLGAnanoparticles and especially its analytical characterisation with regard to a nanosized drug carrier. Besides physico-chemical tablet characterisation according to pharmacopoeias the main goal of the study was the development of a suitable analytical method for the quantification of nanoparticle release from tablets. An analytical flow field-flow fractionation (AF4) method was established and validated which enables determination of nanoparticle content in solid dosage forms as well as quantification of particle release during dissolution testing. For particle detection a multi-angle light scattering (MALS) detector was coupled to the AF4-system."
According to the news editors, the research concluded: "After dissolution testing, the presence of unaltered PLGA-nanoparticles was successfully proved by dynamic light scattering and scanning electron microscopy."
For more information on this research see: Asymmetric flow field-flow fractionation (AF4) for the quantification of nanoparticle release from tablets during dissolution testing. International Journal of Pharmaceutics, 2014;461(1-2):137-144. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
The news correspondents report that additional information may be obtained from A. Engel, University of Munster, Inst Pharmaceut Technol & Biopharm, D-48149 Munster, Germany. Additional authors for this research include M. Ploger, D. Mulac and K. Langer (see also Nanoparticles).
Keywords for this news article include: Europe, Munster, Germany, Nanotechnology, Emerging Technologies
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