By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Nanoparticles. According to news reporting from Piscataway, New Jersey, by NewsRx journalists, research stated, "The prevention of cyto-and genotoxicity of nanocarriers is an important task in nanomedicine. In the present investigation, we, at the first time using similar experimental conditions, compared genotoxicity of nanocarriers with different composition, architecture, size, molecular weight and charge."
The news correspondents obtained a quote from the research from the State University of New Jersey, "Poly(ethylene glycol) polymers, neutral and cationic liposomes, micelles, poly(amindo amine) and poly(propyleneimine) dendrimers, quantum dots, mesoporous silica, and supermagnetic iron oxide (SPIO) nanoparticles were studied. All nanoparticles were used in non-cytotoxic concentrations. However, even in these concentrations, positively charged cationic liposomes, dendrimers, and SPIO nanoparticles induced genotoxicity leading to the significant formation of micronuclei in cells. Negatively charged and neutral nanocarriers were not genotoxic. A strong positive correlation was found between the number of formed micronuclei and the positive charge of nanocarriers."
According to the news reporters, the research concluded: "We proposed modifications of both types of dendrimers and SPIO nanoparticles that substantially decreased their genotoxicity and allowed for an efficient intracellular delivery of nucleic acids."
For more information on this research see: Genotoxicity of different nanocarriers: possible modifications for the delivery of nucleic acids. Current Drug Discovery Technologies, 2013;10(1):8-15. (Bentham Science Publishers - www.benthamscience.com; Current Drug Discovery Technologies - www.benthamscience.com/cddt/index.htm)
Our news journalists report that additional information may be obtained by contacting V. Shah, Dept. of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, United States. Additional authors for this research include O. Taratula, O.B. Garbuzenko, M.L. Patil, R. Savla, M. Zhang and T. Minko (see also Nanoparticles).
Keywords for this news article include: Piscataway, New Jersey, United States, Nanotechnology, Emerging Technologies, North and Central America.
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