By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Enzymes and Coenzymes. According to news reporting originating in Seoul, South Korea, by NewsRx journalists, research stated, "Nanoparticles have been widely used for delivering various chemical and biomolecular drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles have advantages of non-cytotoxicity and biodegradability."
The news reporters obtained a quote from the research from Seoul National University, "In this study, a recombinant 30Kc19 protein was applied to human serum albumin (HSA) nanoparticles to enhance cellular uptake and stability of a nanoparticle cargo enzyme. The 30Kc19 protein, which originates from silkworm, has cell-penetrating and enzyme-stabilizing abilities. Therefore, 30Kc19-HSA nanoparticles were expected to enhance cellular uptake and stability of an enzyme loaded on the nanoparticles. Here, nanoparticles loaded with ?-galactosidase were prepared using the desolvation method. The 30Kc19-HSA nanoparticles were uniformly spherical in shape, dispersed evenly in phosphate buffered saline and cell culture media, and released ?-galactosidase in a sustained manner. The 30Kc19-HSA nanoparticles had negligible toxicity to animal cells and exhibited enhanced cellular uptake and intracellular stability of ?-galactosidase in HeLa and HEK293 cells when compared with those of HSA nanoparticles."
According to the news reporters, the research concluded: "These results suggest that 30Kc19-HSA protein nanoparticles could be used as a versatile tool for drug delivery to various cells."
For more information on this research see: Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles. Biomaterials, 2014;35(5):1696-704. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting H.J. Lee, School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, South Korea. Additional authors for this research include H.H. Park, J.A. Kim, J.H. Park, J. Ryu, J. Choi, J. Lee, W.J. Rhee and T.H Park (see also Enzymes and Coenzymes).
Keywords for this news article include: Asia, Seoul, South Korea, Nanoparticle, Serum Albumin, Blood Proteins, Galactosidases, Nanotechnology, Acute Phase Proteins, Glycoside Hydrolases, Emerging Technologies, Enzymes and Coenzymes.
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