News Column

Studies from Jichi Medical University Update Current Data on Hypersensitivity

February 19, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Immune System Diseases and Conditions have been published. According to news reporting from Tochigi, Japan, by NewsRx journalists, research stated, "Sixty year-old male positive for both HCV-RNA and HBsAg was treated by triple therapy of peginterferon alpha2b, ribavirin and telaprevir. Eight weeks after the beginning of the therapy, the patient developed drug induced hypersensitivity syndrome (DIHS) with general erythema multiforme and 64 times anti-HHV6 antibody elevation."

The news correspondents obtained a quote from the research from Jichi Medical University, "Sixty milligram of prednisolone was administered with gradual dose reduction and the skin lesion was improved. HBV-DNA and transaminase elevated one week after the steroid induction and entecavir improved them."

According to the news reporters, the research concluded: "DIHS itself and the aggravation of hepatitis B by corticosteroid should be kept in mind in cases with dual infection of HBV and HCV treated by antivirals including telaprevin."

For more information on this research see: Drug-Induced Hypersensitivity Syndrome by Triple Therapy of Peginterferon Alpha2b, Ribavirin and Telaprevir in Double-Positive Patient for HBV and HCV. Hepato-Gastroenterology, 2013;60(127):1557-1560. Hepato-Gastroenterology can be contacted at: H G E Update Medical Publishing S A, PO Box 17257, Athens Gr-10024, Greece. (Thieme -

Our news journalists report that additional information may be obtained by contacting H. Takagi, Jichi Med Univ, Sch Med, Dept. of Infect & Immun, Div Virol, Shimotsuke, Tochigi, Japan. Additional authors for this research include T. Hoshino, A. Naganuma, E. Koitabashi, S. Uehara, N. Sakamoto, T. Kudo, K. Ryusaki, S. Kakizaki and H. Okamoto (see also Immune System Diseases and Conditions).

Keywords for this news article include: Asia, Antiretrovirals, Antivirals, Japan, Drugs, Tochigi, Ribavirin, Hypersensitivity, Influenza Therapy, Purine Nucleosides, Respiratory Agents, Inhaled Antiinfectives, Respiratory Inhalant Products, Immune System Diseases and Conditions

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Source: Biotech Week

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