By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Nervous System Diseases and Conditions have been presented. According to news reporting out of Zurich, Switzerland, by NewsRx editors, research stated, "The possibility to control the fate of the cells responsible for secondary mechanisms following spinal cord injury (SCI) is one of the most relevant challenges to reduce the post traumatic degeneration of the spinal cord. In particular, microglia/macrophages associated inflammation appears to be a self-propelling mechanism which leads to progressive neurodegeneration and development of persisting pain state."
Our news journalists obtained a quote from the research from Institute for Chemistry, "In this study we analyzed the interactions between poly(methylmethacrylate) nanoparticles (PMMA-NPs) and microglia/macrophages in vitro and in vivo, characterizing the features that influence their internalization and ability to deliver drugs. The uptake mechanisms of PMMA-NPs were in-depth investigated, together with their possible toxic effects on microglia/macrophages. In addition, the possibility to deliver a mimetic drug within microglia/macrophages was characterized in vitro and in vivo."
According to the news editors, the research concluded: "Drug-loaded polymeric NPs resulted to be a promising tool for the selective administration of pharmacological compounds in activated microglia/macrophages and thus potentially able to counteract relevant secondary inflammatory events in SCI."
For more information on this research see: Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury. Journal of Controlled Release, 2014;174():15-26. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
Our news journalists report that additional information may be obtained by contacting S. Papa, ETH, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland. Additional authors for this research include R. Ferrari, M. De Paola, F. Rossi, A. Mariani, I. Caron, E. Sammali, M. Peviani, V. Dell'Oro, C. Colombo, M. Morbidelli, G. Forloni, G. Perale, D. Moscatelli and P. Veglianese (see also Nervous System Diseases and Conditions).
Keywords for this news article include: Zurich, Europe, Microglia, Neuroglia, Immunology, Switzerland, Macrophages, Myeloid Cells, Spinal Cord Injury, Nervous System Trauma, Central Nervous System, Connective Tissue Cells, Mononuclear Phagocyte System, Nervous System Diseases and Conditions
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