By a News Reporter-Staff News Editor at AIDS Vaccine Week -- Fresh data on Immune System Diseases and Conditions are presented in a new report. According to news reporting out of New York City, New York, by NewsRx editors, research stated, "Adolescents have had very limited access to research on biomedical prevention interventions despite high rates of HIV acquisition. One concern is that adolescents are a vulnerable population, and trials carry a possibility of harm, requiring investigators to take additional precautions."
Our news journalists obtained a quote from the research from the Mount Sinai School of Medicine, "Of particular concern is preventive misconception, or the overestimation of personal protection that is afforded by enrolment in a prevention intervention trial. As part of a larger study of preventive misconception in adolescent HIV vaccine trials, we interviewed 33 male and female 16-19-year-olds who have sex with men. Participants underwent a simulated HIV vaccine trial consent process, and then completed a semistructured interview about their understanding and opinions related to enrolment in a HIV vaccine trial. A grounded theory analysis looked for shared concepts, and focused on the content and process of adolescent participants' understanding of HIV vaccination and the components of preventive misconception, including experiment, placebo and randomisation. Across interviews, adolescents demonstrated active processing of information, in which they questioned the interviewer, verbally worked out their answers based upon information provided, and corrected themselves. We observed a wide variety of understanding of research concepts. While most understood experiment and placebo, fewer understood randomisation. All understood the need for safer sex even if they did not understand the more basic concepts."
According to the news editors, the research concluded: "Education about basic concepts related to clinical trials, time to absorb materials and assessment of understanding may be necessary in future biomedical prevention trials."
For more information on this research see: Preventive misconception and adolescents' knowledge about HIV vaccine trials. Journal of Medical Ethics, 2013;39(12):765-771. Journal of Medical Ethics can be contacted at: Bmj Publishing Group, British Med Assoc House, Tavistock Square, London WC1H 9JR, England. (BMJ Publishing Group - group.bmj.com/; Journal of Medical Ethics - jme.bmj.com/)
Our news journalists report that additional information may be obtained by contacting M.A. Ott, Mt Sinai Sch Med, Dept. of Pediat, New York, NY, United States. Additional authors for this research include A.B. Alexander, M. Lally, J.B. Steever and G.D. Zimet (see also Immune System Diseases and Conditions).
Keywords for this news article include: HIV/AIDS, Vaccines, Virology, RNA Viruses, Retroviridae, New York City, United States, HIV Infections, Vertebrate Viruses, Biological Products, Primate Lentiviruses, North and Central America, Clinical Trials and Studies, Acquired Immunodeficiency Syndrome, Viral Sexually Transmitted Diseases
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