By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Nitrogen. According to news reporting originating in Austin, Texas, by NewsRx journalists, research stated, "Nitrogen-doped carbon nanotubes (N-CNTs) substantially lower the overpotential necessary for dihydronicotinamide adenine dinucleotide (NADH) oxidation compared to nondoped CNTs or traditional carbon electrodes such as glassy carbon (GC). We observe a 370 mV shift in the peak potential (E-p) from GC to CNTs and another 170 mV shift from CNTs to 7.4 atom % N-CNTs in a sodium phosphate buffer solution (pH 7.0) with 2.0 mM NADH (scan rate 10 mV/s)."
The news reporters obtained a quote from the research from the University of Texas, "The sensitivity of 7.4 atom % N-CNTs to NADH was measured at 0.30 +/- 0.04 A M-1 cm(-2), with a limit of detection at 1.1 +/- 0.3 mu M and a linear range of 70 +/- 10 mu M poised at a low potential of -0.32 V (vs Hg/Hg2SO4). NADH fouling, known to occur to the electrode surface during NADH oxidation, was investigated by measuring both the change in E-p and the resulting loss of electrode sensitivity. NADH degradation, known to occur in phosphate buffer, was characterized by absorbance at 340 nm and correlated with the loss of NADH electroactivity. N-CNTs are further demonstrated to be an effective platform for dehydrogenase-based biosensing by allowing glucose dehydrogenase to spontaneously adsorb onto the N-CNT surface and measuring the resulting electrode's sensitivity to glucose."
According to the news reporters, the research concluded: "The glucose biosensor had a sensitivity of 0.032 +/- 0.003 A M-1 cm(-2), a limit of detection at 6 +/- 1 mu M, and a linear range of 440 +/- 50 mu M."
For more information on this research see: Electrochemical Oxidation of Dihydronicotinamide Adenine Dinucleotide at Nitrogen-Doped Carbon Nanotube Electrodes. Analytical Chemistry, 2013;85(19):9135-9141. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)
Our news correspondents report that additional information may be obtained by contacting J.M. Goran, Univ Texas Austin, Dept. of Chem & Biochem, Center Electrochem, Center Nano & Mol Sci & Technol, Austin, TX 78712, United States. Additional authors for this research include C.A. Favela and K.J. Stevenson (see also Nitrogen).
Keywords for this news article include: Texas, Austin, Nitrogen, Chemistry, Fullerenes, United States, Electrochemical, Carbon Nanotubes, North and Central America
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