News Column

Researchers from National University Report Recent Findings in Proinsulin

February 19, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Peptide Proteins have been published. According to news reporting out of Buenos Aires, Argentina, by NewsRx editors, research stated, "This paper addresses the design of blood glucose control during the postprandial period for Type 1 diabetes patients. An artificial pancreas for ambulatory purposes has to deal with the delays inherent to the subcutaneous route, the carbohydrate intakes, the metabolic changes, the glucose sensor errors and noise, and the insulin pump constraints."

Our news journalists obtained a quote from the research from National University, "A time response typically obtained in closed-loop insulin delivery shows hyperglycemia in the early postprandial period caused by the lag in the insulin absorbtion, followed by hypoglycemia caused by control over-reaction. A hybrid control system is proposed in this paper to overcome these problems. An insulin bolus is administered prior to the meals like in open-loop control, whereas a PD controller is used for robust glucose regulation. The controller gain is progressively increased after the bolus from zero up to its nominal value as function of the insulin on board, so that the PD controller becomes fully operational just when the insulin on board falls below a prescribed value. An excessive accumulation of active insulin is avoided in this way, drastically reducing the risk of hypoglycemia. The controller gain is adapted by means of a variable structure algorithm, allowing a very simple software implementation."

According to the news editors, the research concluded: "The robust performance of the control algorithm is intensively assessed in silico on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, discrete measurement and actuation, sensor errors and other disturbances."

For more information on this research see: Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation. Biomedical Signal Processing and Control, 2013;8(6):724-732. Biomedical Signal Processing and Control can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomedical Signal Processing and Control - www.elsevier.com/wps/product/cws_home/706718)

Our news journalists report that additional information may be obtained by contacting F. Leon-Vargas, UNLP, Fac Ingn, LEICI, CONICET, La Plata, Buenos Aires, Argentina. Additional authors for this research include F. Garelli, H. De Battista and J. Vehi (see also Peptide Proteins).

Keywords for this news article include: Argentina, Algorithms, Proinsulin, Buenos Aires, South America, Peptide Hormones, Peptide Proteins

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Source: Biotech Week


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