By a News Reporter-Staff News Editor at Journal of Engineering -- Investigators publish new report on Chemical Engineering. According to news reporting originating in Dortmund, Germany, by VerticalNews journalists, research stated, "Liquid-liquid extraction is a potential separation process for the purification and isolation of pharmaceuticals. However, as considerable experimental effort is required to choose an adequate extractant, liquid-liquid extraction is rarely used in the pharmaceutical industry."
The news reporters obtained a quote from the research from Technical University, "By applying a thermodynamic model to predict the extraction behavior of pharmaceuticals, the experimental effort required to select a suitable extractant can be decreased substantially. This work demonstrates that PC-SAFT is able to predict the extraction behavior of pharmaceuticals based solely on solid solubility data of the pharmaceutical in pure solvents. Because these data are required for pharmaceutical licensing and registration, they are usually available. To demonstrate the power of the modeling tool, six ternary two-phase systems containing a pharmaceutical intermediate or its impurity were modeled with PC-SAFT."
According to the news reporters, the research concluded: "The modeling results for the extraction behavior of the two pharmaceuticals were found to be in good agreement with the experimental data."
For more information on this research see: Predicting the Extraction Behavior of Pharmaceuticals. Industrial & Engineering Chemistry Research, 2014;53(2):865-870. Industrial & Engineering Chemistry Research can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Industrial & Engineering Chemistry Research - www.pubs.acs.org/journal/iecred)
Our news correspondents report that additional information may be obtained by contacting F.S. Laube, Technical Univ Dortmund, Lab Thermodynam, D-44227 Dortmund, Germany.
Keywords for this news article include: Europe, Germany, Dortmund, Chemical Engineering
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