News Column

Reports Outline Stem Cells Study Findings from Children's Hospital

February 19, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Stem Cell Research. According to news originating from Westmead, Australia, by NewsRx correspondents, research stated, "Embryonic/ pluripotent stem cells offer the possibility of an unlimited source of cells to be differentiated into beta cells. This requires differentiating the stem cells into pancreatic progenitors by tissue culture, and then transplanting into recipients for the final stages of development into mature beta-cells."

Our news journalists obtained a quote from the research from Children's Hospital, "Exposing embryonic stem cells seeded onto laminin coated PLGA scaffolds to biochemical cues resulted in enhanced expression of definitive endoderm markers compared to those differentiated on 2D monolayers. The production of tissue specific cells from stem cells can be scaled up using bioreactor cultures. To apply human stem cell derived islet progenitors in a clinical setting, one must first overcome the problem of immune rejection. Immuno-isolating the cells using microencapsulation provides one possible solution. Coating scaffolds with an anti-inflammatory agent could be an effective means of reducing the inflammatory process that results in pericapsular fibrosis and necrosis of the encapsulated cells."

According to the news editors, the research concluded: "This review summarizes the above issues and describes how 3D scaffolds seeded with stem cells and/ or pancreatic progenitors may provide a benefit to achieving normalization of blood glucose levels."

For more information on this research see: Scaffolds for islets and stem cells differentiated into insulin-secreting cells. Frontiers in Bioscience-Landmark, 2014;19():126-138. Frontiers in Bioscience-Landmark can be contacted at: Frontiers In Bioscience Inc, 16471 Scientific Way, Irvine, CA 92618, USA (see also Stem Cell Research).

The news correspondents report that additional information may be obtained from B.E. Tuch, Columbus Children's Hospital, Oncol Res Unit, Westmead, NSW, Australia. Additional authors for this research include S.Y. Gao and J.G. Lees.

Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Westmead, Proinsulin, Bioengineering, Peptide Hormones, Stem Cell Research, Islets of Langerhans, Enteroendocrine Cells, Insulin-Secreting Cells, Australia and New Zealand

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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