News Column

Reports Outline Escherichia Coli Findings from School of Chemical and Biomolecular Engineering

February 19, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Proteobacteria have been presented. According to news reporting originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "Cellobiose is a major intermediate from cellulase hydrolysis of pretreated plant biomass. Engineering biocatalysts for direct use of cellobiose could eliminate the need for exogenous beta-glucosidase."

Our news editors obtained a quote from the research from the School of Chemical and Biomolecular Engineering, "Additionally, rapid removal of cellobiose in a simultaneous saccharification and fermentation facilitates enzymatic hydrolysis as cellobiose is a potent inhibitor for cellulases. We report here improved cellobiose utilization by engineering Escherichia coli to assimilate the disaccharide both hydrolytically and phosphorolytically (shorter fermentation time). Additionally, we demonstrate that engineering intracellular cellobiose utilization circumvents catabolite repression allowing simultaneous fermentation of xylose and cellobiose."

According to the news editors, the research concluded: "Using meso-2,3-butanediol as model product, we further demonstrate that the accelerated carbon metabolism led to improved product formation (higher titers and shorter fermentation times), illustrating the utility of the engineered biocatalysts in biorefinery applications."

For more information on this research see: Improved cellobiose utilization in E-coli by including both hydrolysis and phosphorolysis mechanisms. Biotechnology Letters, 2014;36(2):301-307. Biotechnology Letters can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer -; Biotechnology Letters -

The news editors report that additional information may be obtained by contacting C. Rutter, Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332, United States (see also Proteobacteria).

Keywords for this news article include: Atlanta, Georgia, Engineering, Escherichia, United States, Enterobacteriaceae, Gammaproteobacteria, North and Central America

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Source: Biotech Week

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