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Reports on Biochemistry Findings from University of London Provide New Insights

February 18, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Biochemistry have been presented. According to news reporting originating in London, United Kingdom, by NewsRx journalists, research stated, "Kinesins constitute a superfamily of microtubule-based motor proteins with important cellular functions ranging from intracellular transport to cell division. Some kinesin family members function during the mitotic phase of the eukaryotic cell cycle and are crucial for the successful progression of cell division."

The news reporters obtained a quote from the research from the University of London, "In the early stages of mitosis, during prometaphase, certain kinesins are required for the formation of the bipolar spindle, such as Eg5 and Kif15, which seem to possess partially overlapping functions. Because kinesins transform the chemical energy from ATP hydrolysis into mechanical work, inhibition of their function is a tractable approach for drug development. Drugs targeting Eg5 have shown promise as anticancer agents. Kif15 has recently come to the fore because it can substitute the functions of Eg5, and may itself have potential as a prospective drug target. Here, the initial biochemical, kinetic and structural characterization of Kif15 is reported and it is compared with the functionally related motor Eg5. Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the 'ATP-like' configuration, with the neck linker docked to the catalytic core."

According to the news reporters, the research concluded: "The interaction of Kif15 with microtubules was also investigated and structural differences between these two motors were elucidated which indicate profound differences in their mode of action, in agreement with current models of microtubule cross-linking and sliding."

For more information on this research see: The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development. Acta Crystallographica Section D-Biological Crystallography, 2014;70():123-133. Acta Crystallographica Section D-Biological Crystallography can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA (see also Biochemistry).

Our news correspondents report that additional information may be obtained by contacting M. Klejnot, University of London, Sch Pharm, London WC1N 1AX, United Kingdom. Additional authors for this research include A. Falnikar, V. Ulaganathan, R.A. Cross, P.W. Baas and F. Kozielski.

Keywords for this news article include: Cells, London, Europe, Neurons, Biochemical, Biochemistry, United Kingdom, Nanotechnology, Molecular Motors, Emerging Technologies

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Source: Life Science Weekly

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