News Column

Reports from Rice University Describe Recent Advances in Nanoparticles

February 19, 2014



By a News Reporter-Staff News Editor at Journal of Engineering -- A new study on Nanoparticles is now available. According to news reporting from Houston, Texas, by VerticalNews journalists, research stated, "Advancement of RNAi therapies is mainly hindered by the development of efficient delivery vehicles. The ability to create small size (

The news correspondents obtained a quote from the research from Rice University, "In this report, we describe diblock star polymers that can reproducibly complex double-stranded oligonucleotides into monodisperse nanoparticles with 15, 23, or 30 nm in diameter. The polymer nucleic acid nanoparticles have a core-shell architecture with dense PEG brush coating. We characterized these nanoparticles using ITC, DLS, FRET, FCS, TIRF, and TEM."

According to the news reporters, the research concluded: "In addition to small size, these nanoparticles have neutral zeta-potentials, making the presented polymer architecture a very attractive platform for investigation of yet poorly studied polyplex size range for siRNA and antisense oligonucleotide delivery applications."

For more information on this research see: Precisely Tunable Engineering of Sub-30 nm Monodisperse Oligonucleotide Nanoparticles. Journal of the American Chemical Society, 2014;136(1):234-240. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)

Our news journalists report that additional information may be obtained by contacting A. Sizovs, Rice University, Dept. of Chem, Houston, TX 77030, United States. Additional authors for this research include X.Z. Song, M.N. Waxham, Y.L. Jia, F.D. Feng, J.W. Chen, A.C. Wicker, J.M. Xu, Y. Yu and J. Wang.

Keywords for this news article include: Texas, Houston, Engineering, United States, Nanotechnology, Emerging Technologies, North and Central America

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Source: Journal of Engineering


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