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Reports from Kyung Hee University Highlight Recent Findings in Hydrolases

February 19, 2014



By a News Reporter-Staff News Editor at Biotech Week -- A new study on Enzymes and Coenzymes is now available. According to news reporting from Gyeonggi Do, South Korea, by NewsRx journalists, research stated, "(S)-Styrene oxide, (S)-2-chlorostyrene oxide (CSO), (S)-3-CSO and (S)-4-CSO with 99.9 %ee were obtained with a yield of 20.6, 39.3, 28.7 and 26.8 % from 4 mM corresponding racemic substrates using 10 mg cells of a newly-isolated Sphingopyxis sp. at pH 8.0 and 25 A degrees C in 1 ml 100 mM Tris/HCl buffer after 420, 100, 120 and 55 min, respectively."

The news correspondents obtained a quote from the research from Kyung Hee University, "For racemic 2CSO, well-known for one of the racemates that is difficult to obtained in enantiomerically pure form, (S)-2-CSO with 99.9 %ee, 39.3 % yield (theoretical yield 50 %) and enantiomeric ratio of 42.1 was obtained."

According to the news reporters, the research concluded: "The newly-isolated strain can thus be used as whole-cell biocatalyst in the production of various (S)-CSO with a chlorine group at different positions."

For more information on this research see: Enantioselective hydrolysis of racemic styrene oxide and its substituted derivatives using newly-isolated Sphingopyxis sp exhibiting a novel epoxide hydrolase activity. Biotechnology Letters, 2014;36(2):357-362. Biotechnology Letters can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Biotechnology Letters - www.springerlink.com/content/0141-5492/)

Our news journalists report that additional information may be obtained by contacting J.H. Woo, Kyung Hee Univ, Dept. of Chem Engn, Gyeonggi Do 446701, South Korea (see also Enzymes and Coenzymes).

Keywords for this news article include: Asia, Gyeonggi Do, South Korea, Epoxide Hydrolases, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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