By a News Reporter-Staff News Editor at AIDS Weekly -- New research on Immune System Diseases and Conditions is the subject of a report. According to news reporting out of Glastonbury, Connecticut, by NewsRx editors, research stated, "Spectrum epidemiological models are used by UNAIDS to provide global, regional and national HIV estimates and projections, which are then used for evidence-based health planning for HIV services. However, there are no validations of the Spectrum model against empirical serological and mortality data from populations in sub-Saharan Africa. ]Methods: Serologic, demographic and verbal autopsy data have been regularly collected among over 30,000 residents in north-western Tanzania since 1994."
Our news journalists obtained a quote from the research from Futures Institute, "Five-year age-specific mortality rates (ASMRs) per 1,000 person years and the probability of dying between 15 and 60 years of age ((45)Q(15),) were calculated and compared with the Spectrum model outputs. Mortality trends by HIV status are shown for periods before the introduction of antiretroviral therapy (1994-1999, 2000-2005) and the first 5 years afterwards (2005-2009). Among 30-34 year olds of both sexes, observed ASMRs per 1,000 person years were 13.33 (95% CI: 10.75-16.52) in the period 1994-1999, 11.03 (95% CI: 8.84-13.77) in 2000-2004, and 6.22 (95% CI; 4.75-8.15) in 2005-2009. Among the same age group, the ASMRs estimated by the Spectrum model were 10.55, 11.13 and 8.15 for the periods 1994-1999, 2000-2004 and 2005-2009, respectively. The cohort data, for both sexes combined, showed that the (45)Q(15) declined from 39% (95% CI: 27-55%) in 1994 to 22% (95% CI: 17-29%) in 2009, whereas the Spectrum model predicted a decline from 43% in 1994 to 37% in 2009. From 1994 to 2009, the observed decrease in ASMRs was steeper in younger age groups than that predicted by the Spectrum model, perhaps because the Spectrum model under-estimated the ASMRs in 30-34 year olds in 1994-99."
According to the news editors, the research concluded: "However, the Spectrum model predicted a greater decrease in (45)Q(15) mortality than observed in the cohort, although the reasons for this over-estimate are unclear."
For more information on this research see: Does the Spectrum model accurately predict trends in adult mortality? Evaluation of model estimates using empirical data from a rural HIV community cohort study in north-western Tanzania. Global Health Action, 2014;7():1-8. Global Health Action can be contacted at: Co-Action Publishing, Ripvagen 7, Jarfalla, Se-175 64, Sweden (see also Immune System Diseases and Conditions).
Our news journalists report that additional information may be obtained by contacting D. Michael, Futures Inst, Glastonbury, CT, United States. Additional authors for this research include C. Kanjala, C. Calvert, C. Pretorius, A. Wringe, J. Todd, B. Mtenga, R. Isingo, B. Zaba and M. Urassa.
Keywords for this news article include: HIV/AIDS, Glastonbury, Connecticut, RNA Viruses, Retroviridae, United States, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC