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Reports from Council of Scientific and Industrial Research (CSIR) Describe Recent Advances in Ubiquitins

February 18, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteins have been published. According to news reporting out of Pretoria, South Africa, by NewsRx editors, research stated, "Nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a regulatory component of the I kappa B kinase (IKK) complex, controls NF-kappa B activation through its interaction with ubiquitin chains. We show here that stimulation with interleukin-1 (IL-1) and TNF induces a rapid and transient recruitment of NEMO into punctate structures that are anchored at the cell periphery."

Our news journalists obtained a quote from the research from the Council of Scientific and Industrial Research (CSIR), "These structures are enriched in activated IKK kinases and ubiquitinated NEMO molecules, which suggests that they serve as organizing centers for the activation of NF-kappa B. These NEMO-containing structures colocalize with activated TNF receptors but not with activated IL-1 receptors. We investigated the involvement of nondegradative ubiquitination in the formation of these structures, using cells deficient in K63 ubiquitin chains or linear ubiquitin chain assembly complex (LUBAC)mediated linear ubiquitination. Our results indicate that, unlike TNF, IL-1 requires K63-linked and linear ubiquitin chains to recruit NEMO into higher-order complexes."

According to the news editors, the research concluded: "Thus, different mechanisms are involved in the recruitment of NEMO into supramolecular complexes, which appear to be essential for NF-kappa B activation."

For more information on this research see: TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures. Journal of Cell Biology, 2014;204(2):231-245. Journal of Cell Biology can be contacted at: Rockefeller Univ Press, 1114 First Ave, 4TH Fl, New York, NY 10021, USA (see also Proteins).

Our news journalists report that additional information may be obtained by contacting N. Tarantino, CSIR, Gene Express & Biophys Grp, Synthet Biol Emerging Res Area, Biosci Unit, ZA-0001 Pretoria, Gauteng, South Africa. Additional authors for this research include J.Y. Tinevez, E.F. Crowell, B. Boisson, R. Henriques, M. Mhlanga, F. Agou, A. Israel and E. Laplantine.

Keywords for this news article include: Pretoria, NF-kappa B, Ubiquitins, South Africa, Nanotechnology, Supramolecular, Nuclear Proteins, DNA-Binding Proteins, Emerging Technologies, Transcription Factors

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Source: Life Science Weekly

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