Patent number 8641774 is assigned to The Curators of the
The following quote was obtained by the news editors from the background information supplied by the inventors: "Osteochondral defects in adult knees are a common clinical finding. The limited reparative potential of such osteochondral defects has motivated numerous studies aimed at finding improved methods of treatment. Currently used procedures such as abrasion arthroplasty and microfracture, autologous chondrocyte implantation, osteochondral autografts and allografts, and partial or total joint arthroplasties have yielded varying levels of success. All current techniques suffer from deficiencies, such as donor site morbidity, limited tissue supply, immunorejection, potential transmission of pathogens, and implant loosening. Because of these issues, the development of a tissue-engineered osteochondral composite has attracted interest.
"The creation of tissue-engineered osteochondral composites requires living chondrogenic cells. Commonly used cells in tissue engineering are mesenchymal stem cells (MSCs) which are multipotent progenitor cells that can undergo differentiation into other cell types, including chondrocytes. In addition, tissue-engineered osteochondral composites require synthetic substitutes for the cartilaginous extracellular matrix and subchondral support material.
"The efficacy of existing tissue-engineered osteochondral composites has been hampered by the difficulty of bonding the softer material used for artificial cartilaginous extracellular matrix to the harder material used for the subchondral support material. In existing tissue-engineered osteochondral composites, the cartilaginous matrix material has been bonded to a porous ceramic or metal support material using sutures or surgical glue. To date, existing tissue-engineered osteochondral composites have had limited success due to problems associated with the separation of the artificial cartilaginous extracellular matrix from the underlying subchondral support.
"Therefore, there is a need to provide a new and improved osteochondral composite and a method for fabrication thereof such that a strong and durable bond is established between the artificial cartilaginous extracellular matrix and the underlying subchondral support."
In addition to the background information obtained for this patent, NewsRx journalists also obtained the inventors' summary information for this patent: "An osteochondral composite and method of fabrication thereof that allows homogeneous cell seeding and provides sufficient mechanical support at the same time is disclosed. In one embodiment, the osteochondral composite may include a porous supportive base with an upper surface and a lower surface. In one aspect, the osteochondral composite may include a scaffolding layer with an upper surface and a lower surface with the lower surface of the scaffolding layer being mechanically interlocked with the upper surface of the porous supportive base. In an embodiment, the scaffolding layer may incorporate biological cells implanted into a hydrogel.
"In another embodiment, an osteochondral composite may include three mechanically interlocked layers: a porous base layer, a transitional layer, and a scaffolding layer. In particular, the osteochondral composite includes a porous base layer with an upper and lower surface. The lower surface of a transitional layer is bonded to the upper surface of the porous base layer. To the upper surface of the transitional layer, the lower surface of a scaffolding layer is bonded. The scaffolding layer also includes an upper surface and incorporates a hydrogel material with implanted biologic cells.
"In a further embodiment, a method of fabricating an osteochondral composite is also disclosed. Specifically, a suspension of polymer and biological cells as well as a porous base with an upper and lower surface is provided. The upper surface of the porous base is submerged into the suspension to a predetermined depth. The polymers in the suspension are then crosslinked such that a hydrogel that is mechanically interlocked with the porous base is formed.
"In yet another embodiment, a method of treating diseased or damaged articular cartilage in a vertebrate animal is disclosed. The method of treatment may include providing an osteochondral composite that incorporates a porous base mechanically interlocked to a hydrogel containing implanted biological cells. The osteochondral composite may be implanted within the joint of the vertebrate animal."
URL and more information on this patent, see: Rahaman,
Keywords for this news article include: Alcohols, Hydrogel, Treatment, Engineering, Organic Chemicals, Extracellular Space, Extracellular Matrix, Polyethylene Glycols, The Curators of the
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