The assignee for this patent, patent number 8640643, is
Reporters obtained the following quote from the background information supplied by the inventors: "Localized and systemic infections represent one of the most serious post surgical complications. Over the past fifty years tremendous advances in materials, training and antimicrobial therapies have significantly reduced the number of life-threatening post operative infections. The development of pre-sterilized disposable surgical dressings, medical instruments, gowns, drapes and other materials have helped reduce infection frequency. However, the development of improved antimicrobials represents the single most significant advance in infection control.
"Deep tissue infections can result when medical implants become contaminated prior to or during surgical placement. When oral or parenterally administered antimicrobials fail to effectively control and eliminate the infection, the medical implant may have to be removed. Removal requires additional surgical procedures to treat the infection as well as to re-implant the device after the infection completely resolves. Moreover, once deep tissue infections are established, long term antimicrobial therapy and hospitalization may be required. These additional procedures increase the costs associated with device implantation, subject the patient to discomfort and in rare circumstances can result in severe long term health issues such as, increasing the threat of permanent disfigurement.
"Coating implantable medical devices with antimicrobial compounds allows for deep tissue drug delivery that can significantly reduce the risk of post implantation infections. Coating procedures should employ broad spectrum antimicrobials that are effective against most post surgical infections, especially MRSA (multiple-resistant Staphylococcus aureus) infections. The antimicrobials must be soluble in physiological fluids and stable enough to survive processing steps required to successfully coat the medical device. Ideally, a synergistic antimicrobial combination should be used. In addition, the size, shape and composition of the medical devices can significantly impact the success of the coating procedure.
"One representative example of an implantable medical device coated with antimicrobial compounds include INHIBIZONE treatment products developed and sold by
"While, the INHIBIZONE treatment products are successful in reducing the occurrence of infection with implantable medical devices, it would be advantageous to further improve upon the coating process so as to more precisely control loading of the implantable medical device with the antimicrobial agent."
In addition to obtaining background information on this patent, NewsRx editors also obtained the inventor's summary information for this patent: "The present disclosure relates to systems and methods of regulating the coating of implantable medical devices with antimicrobial agents. Specifically, the present invention discloses systems and methods for controlling the characteristics of the antimicrobial coating of implantable medical devices by manipulating the loading of antimicrobial agent into a coating medium affixed to the outer surface of the implantable medical device.
"It is an object of the present invention to provide systems and methods for regulating the loading of antimicrobial agents into a coating medium for the coating of a medical device. The present invention also provides systems and methods for applying reproducible coatings to medical devices by providing means for adjusting the amount of antimicrobial agents loadable into the coating medium to create coatings with more consistent characteristics.
"In one aspect, the present disclosure is directed at a system for loading a coating medium affixed to an implantable medical device with antimicrobial agents. Typically, the coating medium is loosely affixed to the outer surface of the implantable medical device. An antimicrobial treatment is then applied to the outside surface of the coating medium. The antimicrobial agents are loaded into the coating medium by diffusing into a network of fibril void spaces within the coating medium. The coating medium is then treated again to form a coating on the implantable medical device. The loading capacity of the coating medium for antimicrobial agents directly affects the characteristics of the coating as the amount of antimicrobial agents loaded into the coating medium will change the characteristics of the coating. The present disclosure is directed to a system for controlling the loading capacity of the coating medium to control the characteristics of the coating formed on the surface of the implantable medical device.
"In another aspect, the present disclosure is directed at a system for producing reproducible coatings on implantable medical devices by controlling the loading capacity of the coating sleeve. Specifically, the disclosure is directed at a system and method of manipulating the volume of the fibril void spaces within the coating medium to control the loading capacity of various portions of the coating sleeve to load different amounts of antimicrobial agents into the various regions.
"In another aspect, the present invention is directed at a system for creating different coating regions on the outer surface of the implantable medical device. Specifically the disclosure is directed at a system and method for manipulating the coating medium wherein different regions of the coating medium have different fibril void space volumes. The differing fibril void space volumes of the various regions will ultimately cause coating regions with different coating characteristics on the implantable medical device.
"The above summary of the various representative embodiments of the invention is not intended to describe each illustrated embodiment or every implementation of the invention. Rather, the embodiments are chosen and described so that others skilled in the art may appreciate and understand the principles and practices of the invention. The figures in the detailed description that follow more particularly exemplify these embodiments."
For more information, see this patent: Wenc, Kate Elaine. Method for Controlling Drug Loading in a Medical Device. U.S. Patent Number 8640643, filed
Keywords for this news article include: Antimicrobials, Surgery, Therapy, Treatment, Medical Devices,
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