By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Oncology are discussed in a new report. According to news reporting from Ann Arbor, Michigan, by NewsRx journalists, research stated, "Protein kinases represent the most effective class of therapeutic targets in cancer; therefore, determination of kinase aberrations is a major focus of cancer genomic studies. Here, we analyzed transcriptome sequencing data from a compendium of 482 cancer and benign samples from 25 different tissue types, and defined distinct 'outlier kinases' in individual breast and pancreatic cancer samples, based on highest levels of absolute and differential expression."
The news correspondents obtained a quote from the research from the University of Michigan School of Medicine, "Frequent outlier kinases in breast cancer included therapeutic targets like ERBB2 and FGFR4, distinct from MET, AKT2, and PLK2 in pancreatic cancer. Outlier kinases imparted sample-specific dependencies in various cell lines, as tested by siRNA knockdown and/or pharmacologic inhibition. Outlier expression of polo-like kinases was observed in a subset of KRAS-dependent pancreatic cancer cell lines, and conferred increased sensitivity to the pan-PLK inhibitor BI-6727."
According to the news reporters, the research concluded: "Our results suggest that outlier kinases represent effective precision therapeutic targets that are readily identifiable through RNA sequencing of tumors."
For more information on this research see: Outlier kinase expression by RNA sequencing as targets for precision therapy. Cancer Discovery, 2013;3(3):280-93. (American Association for Cancer Research - www.aacr.com; Cancer Discovery - cancerdiscovery.aacrjournals.org/)
Our news journalists report that additional information may be obtained by contacting V. Kothari, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States. Additional authors for this research include I. Wei, S. Shankar, S. Kalyana-Sundaram, L. Wang, L.W. Ma, P. Vats, C.S. Grasso, D.R. Robinson, Y.M. Wu, X. Cao, D.M. Simeone, A.M. Chinnaiyan and C. Kumar-Sinha (see also Oncology).
Keywords for this news article include: Kinase, Therapy, Michigan, Genetics, Oncology, Ann Arbor, United States, Gastroenterology, Pancreatic Cancer, Pancreatic Neoplasms, Enzymes and Coenzymes, North and Central America.
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