News Column

New Nanomaterials Study Findings Reported from University of Iowa

February 18, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Nanomaterials have been published. According to news reporting out of Iowa City, Iowa, by NewsRx editors, research stated, "To overcome the limitations of in vitro exposure of submerged lung cells to nanoparticles (NPs), we validated an integrated low flow system capable of generating and depositing airborne NPs directly onto cells at an air-liquid interface (ALI). The in vitro exposure system was shown to provide uniform and controlled dosing of particles with 70.3% efficiency to epithelial cells grown on transwells."

Our news journalists obtained a quote from the research from the University of Iowa, "This system delivered a continuous airborne exposure of NPs to lung cells without loss of cell viability in repeated 4h exposure periods. We sequentially exposed cells to air-delivered copper (Cu) NPs in vitro to compare toxicity results to our prior in vivo inhalation studies. The evaluation of cellular dosimetry indicated that a large amount of Cu was taken up, dissolved and released into the basolateral medium (62% of total mass). Exposure to Cu NPs decreased cell viability to 73% (p

According to the news editors, the research concluded: "Our results show that this exposure system is useful for screening of NP toxicity in a manner that represents cellular responses of the pulmonary epithelium in vivo."

For more information on this research see: Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials. Toxicology In Vitro, 2013;27(1):164-73. (Elsevier -; Toxicology In Vitro -

Our news journalists report that additional information may be obtained by contacting J.S. Kim, Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52242-5000, United States. Additional authors for this research include T.M. Peters, P.T. O'Shaughnessy, A. Adamcakova-Dodd and P.S Thorne (see also Nanomaterials).

Keywords for this news article include: Iowa City, United States, Nanotechnology, Emerging Technologies, North and Central America.

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Source: Life Science Weekly

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