News Column

New Heparin Therapy Study Results Reported from Oregon Health and Science University

February 20, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Data detailed on Drugs and Therapies have been presented. According to news reporting originating from Portland, Oregon, by NewsRx correspondents, research stated, "Adeno-associated virus (AAV) is a key candidate in the development of gene therapy. In this work, we used surface plasmon resonance spectroscopy to study the interaction between AAV and heparin and other glycosaminoglycans (GAGs)."

Our news editors obtained a quote from the research from Oregon Health and Science University, "Surface plasmon resonance results revealed that heparin binds to AAV with an extremely high affinity. Solution competition studies showed that binding of AAV to heparin is chain length dependent AAV prefers to bind full la chain heparin. All sulfo groups (especially N-sulfo and 6-O-sulfo groups) on heparin are important for the AAV heparin interaction. Higher levels of sulfo group substitution in GAGs enhance their binding affinities."

According to the news editors, the research concluded: "Atomic force microscopy was also performed to image AAV-2 in a complex with heparin."

For more information on this research see: Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-Associated Virus. Biochemistry, 2013;52(36):6275-6285. Biochemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biochemistry - www.pubs.acs.org/journal/bichaw)

The news editors report that additional information may be obtained by contacting F.M. Zhang, Oregon Health Sciences University, Sch Med, Dept. of Biochem & Mol Biol, Portland, OR 97239, United States. Additional authors for this research include J. Aguilera, J.M. Beaudet, Q. Xie, T.F. Lerch, O. Davulcu, W. Colon, M.S. Chapman and R.J. Linhardt (see also Drugs and Therapies).

Keywords for this news article include: Biotechnology, Oregon, Heparin, Viruses, Portland, Virology, Gene Therapy, United States, Bioengineering, Drugs and Therapies, North and Central America

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Source: Gene Therapy Weekly


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