News Column

New Findings from Tokyo University of Agriculture in the Area of Saccharomyces cerevisiae Reported

February 18, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Saccharomyces cerevisiae are discussed in a new report. According to news reporting originating in Tokyo, Japan, by NewsRx journalists, research stated, "We isolated 2,4-dinitrophenol (DNP)-resistant sake yeast strains by UV mutagenesis. Among the DNP-resistant mutants, we focused on strains exhibiting high malic acid and low acetic acid production."

The news reporters obtained a quote from the research from the Tokyo University of Agriculture, "The improved organic acid composition is unlikely to be under the control of enzyme activities related to malic and acetic acid synthesis pathways. Instead, low mitochondrial activity was observed in DNP-resistant mutants, indicating that the excess pyruvic acid generated during glycolysis is not metabolized in the mitochondria but converted to malic acid in the cytosol. In addition, the NADH/NAD(+) ratio of the DNP-resistant strains was higher than that of the parental strain K901."

According to the news reporters, the research concluded: "These results suggest that the increased NADH/NAD(+) ratio together with the low mitochondrial activity alter the organic acid composition because malic acid synthesis requires NADH, while acetic acid uses NAD(+)."

For more information on this research see: Isolation of a high malic and low acetic acid-producing sake yeast Saccharomyces cerevisiae strain screened from respiratory inhibitor 2,4-dinitrophenol (DNP)-resistant strains. Journal of Bioscience and Bioengineering, 2014;117(1):39-44. (Elsevier - www.elsevier.com; Journal of Bioscience and Bioengineering - www.elsevier.com/wps/product/cws_home/505516)

Our news correspondents report that additional information may be obtained by contacting S. Kosugi, Dept. of Fermentation Science and Technology, Faculty of Applied Bio-science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-ku, Tokyo 156-8502, Japan. Additional authors for this research include K. Kiyoshi, T. Oba, K. Kusumoto, T. Kadokura, A. Nakazato and S. Nakayama (see also Saccharomyces cerevisiae).

Keywords for this news article include: Asia, Tokyo, Japan, Acetic Acids, Acyclic Acids, Life Sciences, Dinitrophenols, Saccharomycetales, Saccharomycetaceae, Saccharomyces cerevisiae.

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Source: Life Science Weekly


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