By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting originating from Princeton, New Jersey, by NewsRx correspondents, research stated, "The formation of 10-40 mu m composite gel microparticles (CGMPs) comprised of similar to 100 nm drug containing nanoparticles (NPs) in a poly(ethylene glycol) (PEG) gel matrix is described. The CGMP particles enable targeting to the lung by filtration from the venous circulation."
Our news editors obtained a quote from the research from Princeton University, "UV radical polymerization and Michael addition polymerization reactions are compared as approaches to form the PEG matrix. A fluorescent dye in the solid core of the NP was used to investigate the effect of reaction chemistry on the integrity of encapsulated species. When formed via UV radical polymerization, the fluorescence signal from the NPs indicated degradation of the encapsulated species by radical attack. The degradation decreased fluorescence by 90% over 15 min of UV exposure. When formed via Michael addition polymerization, the fluorescence was maintained. Emulsion processing using controlled shear stress enabled control of droplet size with narrow polydispersity. To allow for emulsion processing, the gelation rate was delayed by adjusting the solution pH. At a pH = 5.4, the gelation occurred at 3.5 h. The modulus of the gels was tuned over the range of 5 to 50 kPa by changing the polymer concentration between 20 and 70 vol %. NP aggregation during polymerization, driven by depletion forces, was controlled by the reaction kinetics. The ester bonds in the gel network enabled CGMP degradation. The gel modulus decreased by 50% over 27 days, followed by complete gel degradation after 55 days. This permits ultimate clearance of the CGMPs from the lungs."
According to the news editors, the research concluded: "The demonstration of uniform delivery of 15.8 +/- 2.6 mu m CGMPs to the lungs of mice, with no deposition in other organs, is shown, and indicates the ability to concentrate therapeutics in the lung while avoiding off-target toxic exposure."
For more information on this research see: Gelation Chemistries for the Encapsulation of Nanoparticles in Composite Gel Microparticles for Lung Imaging and Drug Delivery. Biomacromolecules, 2014;15(1):252-261. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)
The news editors report that additional information may be obtained by contacting N.M. Pinkerton, Princeton University, Dept. of Mech & Aerosp Engn, Princeton, NJ 08544, United States. Additional authors for this research include S.W. Zhang, R.L. Youngblood, D.Y. Gao, S.K. Li, B.R. Benson, J. Anthony, H.A. Stone, P.J. Sinko and R.K. Prud'homme (see also Drugs and Therapies).
Keywords for this news article include: Princeton, New Jersey, Nanoparticle, United States, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, North and Central America
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