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New Findings from National Center for Scientific Research (CNRS) in the Area of Proteomics Described

February 18, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteomics. According to news reporting originating from Villeurbanne, France, by NewsRx correspondents, research stated, "Gadolinium based Small Rigid Plaforms (SRPs) have previously demonstrated their efficiency for multimodal imaging and radiosensitization. Since the RGD sequence is well-known to be highly selective for alpha(v)beta(3) integrins, a cyclic pentapeptide containing the RGD motif (cRGDfK) has been grafted onto the SRP surface."

Our news editors obtained a quote from the research from National Center for Scientific Research (CNRS), "An appropriate protocol led to the grafting of two targeting ligands per nano-object. The resulting nanoparticles have demonstrated a strong association with alpha(v)beta(3) integrins in comparison with cRADfK grafted SRPs as negative control. Flow cytometry and fluorescence microscopy have also been used to highlight the ability of the nanoparticles to target efficiently HEK293(beta 3) and U87MG cells."

According to the news editors, the research concluded: "Finally the grafted radiosensitizing nanoparticles were intravenously injected into Nude mice bearing subcutaneous U87MG tumors and the signal observed by optical imaging was twice as high for SRP-cRGDfK compared to their negative analogue."

For more information on this research see: Functionalization of Small Rigid Platforms with Cyclic RGD Peptides for Targeting Tumors Overexpressing alpha(v)beta(3)-Integrins. Bioconjugate Chemistry, 2013;24(9):1584-1597. Bioconjugate Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Bioconjugate Chemistry - www.pubs.acs.org/journal/bcches)

The news editors report that additional information may be obtained by contacting J. Morlieras, Inst Natl Sci Appl, CNRS, UMR 5510, F-69621 Villeurbanne, France. Additional authors for this research include S. Dufort, L. Sancey, C. Truillet, A. Mignot, F. Rossetti, M. Dentamaro, S. Laurent, L. Vander Elst, R.N. Muller, R. Antoine, P. Dugourd, S. Roux, P. Perriat, F. Lux, J.L. Coll and O. Tillement (see also Proteomics).

Keywords for this news article include: France, Europe, Peptides, Proteins, Proteomics, Amino Acids, Villeurbanne, Nanoparticle, Nanotechnology, Emerging Technologies

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Source: Life Science Weekly


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