News Column

New Cardiology Study Findings Recently Were Reported by Researchers at Heart and Vascular Institute

February 20, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators discuss new findings in Cardiology. According to news reporting from Charlotte, North Carolina, by NewsRx journalists, research stated, "During the last two decades the fields of molecular and cellular cardiology, and more recently molecular cardiac surgery, have developed rapidly. The concept of delivering cDNA encoding a therapeutic gene to cardiomyocytes using a vector system with substantial cardiac tropism, allowing for long-term expression of a therapeutic protein, has moved from hypothesis to bench to clinical application."

The news correspondents obtained a quote from the research from Heart and Vascular Institute, "However, the clinical results to date are still disappointing. The ideal gene transfer method should be explored in clinically relevant animal models of heart disease to evaluate the relative roles of specific molecular pathways in disease pathogenesis, helping to validate the potential targets for therapeutic intervention. Successful clinical cardiovascular gene therapy also requires the use of nonimmunogenic cardiotropic vectors capable of expressing the requisite amount of therapeutic protein in vivo and in situ. Depending on the desired application either regional or global myocardial gene delivery is required."

According to the news reporters, the research concluded: "Cardiac-specific delivery techniques incorporating mapping technologies for regional delivery and highly efficient methodologies for global delivery should improve the precision and specificity of gene transfer to the areas of interest and minimize collateral organ gene expression."

For more information on this research see: The road ahead: working towards effective clinical translation of myocardial gene therapies. Therapeutic Delivery, 2014;5(1):39-51 (see also Cardiology).

Our news journalists report that additional information may be obtained by contacting M.G. Katz, 1001 Blythe Blvd, Suite 300, Charlotte, NC 28203, Sanger Heart & Vascular Institute, Carolinas Healthcare System, Charlotte NC, United States. Additional authors for this research include A.S. Fargnoli, R.D. Williams and C.R Bridges.

Keywords for this news article include: Biotechnology, Charlotte, Cardiology, Gene Therapy, United States, North Carolina, Bioengineering, North and Central America.

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Source: Gene Therapy Weekly

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