By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biosensing. According to news reporting originating from Singapore, Singapore, by NewsRx correspondents, research stated, "Analysis of molecular interaction and conformational dynamics of biomolecules is of paramount importance in understanding their vital functions in complex biological systems, disease detection, and new drug development. Plasmonic biosensors based upon surface plasmon resonance and localized surface plasmon resonance have become the predominant workhorse for detecting accumulated biomass caused by molecular binding events."
Our news editors obtained a quote from the research from Nanyang Technological University, "However, unlike surface-enhanced Raman spectroscopy (SERS), the plasmonic biosensors indeed are not suitable tools to interrogate vibrational signatures of conformational transitions required for biomolecules to interact. Here, we show that highly tunable plasmonic metamaterials can offer two transducing channels for parallel acquisition of optical transmission and sensitive SERS spectra at the biointerface, simultaneously probing the conformational states and binding affinity of biomolecules, e.g., G-quadruplexes, in different environments."
According to the news editors, the research concluded: "We further demonstrate the use of the metamaterials for fingerprinting and detection of the arginine-glycine-glycine domain of nucleolin, a cancer biomarker that specifically binds to a G-quadruplex, with the picomolar sensitivity."
For more information on this research see: Metamaterials-Based Label-Free Nanosensor for Conformation and Affinity Biosensing. ACS Nano, 2013;7(9):7583-7591. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news editors report that additional information may be obtained by contacting C. Cao, Nanyang Technological University, Sch Elect & Elect Engn, Nanoelect Center Excellence, NOVITAS, Singapore 639798, Singapore. Additional authors for this research include J. Zhang, X.L. Wen, S.L. Dodson, N.T. Dao, L.M. Wong, S.J. Wang, S.Z. Li, A.T. Phan and Q.H. Xiong (see also Biosensing).
Keywords for this news article include: Asia, Biosensing, Bioengineering, Bionanotechnology, Nanobiotechnology
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