By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting from Haryana, India, by NewsRx journalists, research stated, "The interaction between carboxymethyl gum kondagogu and chitosan was optimized to prepare polyelectrolyte complex nanoparticles using ofloxacin as the model drug. The effect of concentrations of carboxymethyl gum kondagogu and chitosan on the particle size and % drug entrapment was screened using 2-factor, 3-level central composite experimental design."
The news correspondents obtained a quote from the research from the Guru Jambheshwar University of Science and Technology, "The results revealed that the concentration of carboxymethyl gum kondagogu has a pronounced effect on the particle size while the concentration of chitosan affected the drug entrapment prominently. The optimized concentrations of carboxymethyl gum kondagogu and chitosan were 0.031% (w/v) and 0.059% (w/v) respectively. The optimized batch of nanoparticles had a particle size of 285.9 nm, entrapment efficiency of 63% and was observed to be ovoid in shape. Screening of ofloxacin-loaded nanoparticles for antibacterial activity with aqueous ofloxacin solution revealed no significant difference between the two formulations."
According to the news reporters, the research concluded: "Nanoparticles provided a sustained release with 50% of the drug getting released in 24 h following Higuchi's square-root kinetics."
For more information on this research see: Carboxymethyl gum kondagogu-chitosan polyelectrolyte complex nanoparticles: Preparation and characterization. International Journal of Biological Macromolecules, 2013;62():80-84. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
Our news journalists report that additional information may be obtained by contacting A. Kumar, Guru Jambheshwar Univ Sci & Technol, Dept. of Pharmaceut Sci, Drug Delivery Res Lab, Hisar 125001, Haryana, India (see also Drugs and Therapies).
Keywords for this news article include: Asia, Antibiotics, India, Haryana, Ofloxacin, Quinolones, Nanoparticle, Nanotechnology, Topical Agents, Otic Preparations, Drugs and Therapies, Otic Antiinfectives, Emerging Technologies, Ophthalmic Preparations, Ophthalmic Antiinfectives
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC