By a News Reporter-Staff News Editor at Clinical Oncology Week -- Research findings on Oncology are discussed in a new report. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, "Organic-inorganic hybrid nanoparticles with calciumphosphate (CaP) core and PEGylated shell were developed to incorporatemagnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid gadolinium (III) (Gd-DTPA) for noninvasive diagnosis of solid tumors. A two-step preparation method was applied to elaborate hybrid nanoparticleswith a z-average hydrodynamic diameter about 80 nm, neutral surface xi-potential and high colloidal stability in physiological environments by self-assembly of poly(ethylene glycol)-b-poly(aspartic acid) block copolymer, Gd-DTPA, and CaP in aqueous solution, followed with hydrothermal treatment."
Our news journalists obtained a quote from the research from the University of Tokyo, "Incorporation into the hybrid nanoparticles allowed Gd-DTPA to show significant enhanced retention ratio in blood circulation, leading to high accumulation in tumor positions due to enhanced permeability and retention (EPR) effect. Moreover, Gd-DTPA revealed above 6 times increase of relaxivity in the nanoparticle system compared to free form, and eventually, selective and elevated contrast enhancements in the tumor positions were observed."
According to the news editors, the research concluded: "These results indicate the high potential of Gd-DTPA-loaded PEGylated CaP nanoparticles as a novel contrast agent for noninvasive cancer diagnosis."
For more information on this research see: Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors. Journal of Controlled Release, 2014;174():63-71. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
Our news journalists report that additional information may be obtained by contacting P. Mi, University of Tokyo, Grad Sch Engn, Dept. of Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan. Additional authors for this research include D. Kokuryo, H. Cabral, M. Kumagai, T. Nomoto, I. Aoki, Y. Terada, A. Kishimura, N. Nishiyama and K. Kataoka (see also Oncology).
Keywords for this news article include: Asia, Tokyo, Japan, Anions, Oncology, Nanoparticle, Solid Cancers, Nanotechnology, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Inorganic Chemicals, Phosphorus Compounds, Emerging Technologies
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