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Investigators from School of Biotechnology Zero in on Cancer Gene Therapy

February 17, 2014

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Fresh data on Biotechnology are presented in a new report. According to news originating from Stockholm, Sweden, by NewsRx correspondents, research stated, "One subproject within the global Chromosome 19 Consortium is to define chromosome 19 gene and protein expression in glioma-derived cancer stem cells (GSCs). Chromosome 19 is notoriously linked to glioma by 1p/19q codeletions, and clinical tests are established to detect that specific aberration."

Our news journalists obtained a quote from the research from the School of Biotechnology, "GSCs are tumor-initiating cells and are hypothesized to provide a repository of cells in tumors that can self-replicate and be refractory to radiation and chemotherapeutic agents developed for the treatment of tumors. In this pilot study, we performed RNA-Seq, label-free quantitative protein measurements in six GSC lines, and targeted transcriptomic analysis using a chromosome 19-specific microarray in an additional six GSC lines. The data have been deposited to the ProteomeXchange with identifier PXD000563. Here we present insights into differences in GSC gene and protein expression, including the identification of proteins listed as having no or low evidence at the protein level in the Human Protein Atlas, as correlated to chromosome 19 and GSC subtype. Furthermore, the upregulation of proteins downstream of adenovirus-associated integration site 1 (AAVS1) in GSC11 in response to oncolytic adenovirus treatment was demonstrated."

According to the news editors, the research concluded: "Taken together, our results may indicate new roles for chromosome 19, beyond the 1p/19q codeletion, in the future of personalized medicine for glioma patients."

For more information on this research see: Integrated Chromosome 19 Transcriptomic and Proteomic Data Sets Derived from Glioma Cancer Stem-Cell Lines. Journal of Proteome Research, 2014;13(1):191-199. Journal of Proteome Research can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Journal of Proteome Research -

The news correspondents report that additional information may be obtained from C.F. Lichti, Alballova Univ Center, Royal Inst Technol, Dept. of Prote, Sch Biotechnol, S-10691 Stockholm, Sweden. Additional authors for this research include H.L. Liu, A.S. Shavkunov, E. Mostovenko, E.P. Sulman, R. Ezhilarasan, Q.H. Wang, R.A. Kroes, J.C. Moskal, D. Fenyo, B.A. Oksuz, C.A. Conrad, F.F. Lang, F.S. Berven, A. Vegvari, M. Rezeli, G. Marko-Varga, S. Hober and Nilsson (see also Biotechnology).

Keywords for this news article include: Biotechnology, Sweden, Europe, Glioma, Genetics, Oncology, Stockholm, Treatment, Proteomics, Chromosomes, Cell Nucleus, Intranuclear Space, Stem Cell Research, Cancer Gene Therapy, Cellular Structures, Intracellular Space, Clinical Trials and Studies

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Source: Cancer Gene Therapy Week

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