By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Polyethylene Glycols are presented in a new report. According to news reporting originating in Beijing, People's Republic of China, by NewsRx journalists, research stated, "As a sustained-release drug depot for localized cancer treatment, in situ thermo-sensitive hydrogel has attracted increasing interests. However, it is currently a big challenge to achieve high drug-loading, sustained and stable drug release, as well as long-term local drug retention simultaneously."
The news reporters obtained a quote from the research from Food and Drug Administration, "We hypothesized that this goal could be accomplished by incorporating the nanocrystals (NCs) of a hydrophobic drug, such as paclitaxel (PTX) into the thermo-sensitive hydrogel (Gel). Hence, a PTX-NCs-Gel system has been constructed with thermosensitive Pluronic F127, using PTX-NCs and Taxol ® as the controls. Besides, near infra-red agent DiR was used to prepare PTX/DiR hybrid NCs and PTX/DiR hybrid NCs-Gel as well. As a result, this hydrogel system could achieve a high drug loading of PTX up to 3 mg/ml while stabilize the particle size of PTX-NCs significantly compared with PTX-NCs alone. There was no obvious interaction between PTX-NCs and F127. Obviously, PTX/DiR hybrid NCs- Gel presented better localized retention capacity and a much longer retention time in murine 4T1 tumor than PTX/DiR hybrid NCs and Cremophor/ethanol solubilized DiR in vivo. With a linear elimination, over 10% of PTX still remained inside of mouse 4T1 tumor 20 days after intratumoral dosing of PTX-NCs-Gel. Importantly, PTX-NCs exhibited comparable cytotoxity against 4T1 and MCF-7 cells in vitro compared with Taxol ®, which could ensure the efficacy of PTX-NCs-Gel. After intratumoral injection, PTX-NCs-Gel was found to be the most effective among all PTX formulations in the 4T1 and MCF-7 tumor-bearing mice models, with much lower system toxicity than Taxol ®."
According to the news reporters, the research concluded: "In general, it is believed that the novel thermo-sensitive hydrogel system prepared in this study with PTX-NCs affords high drug-loading, sustained and stable drug release, as well as extended drug retention inside of tumor, which results in better therapy and lower toxicity."
For more information on this research see: Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity. Journal of Controlled Release, 2014;174():161-170. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
Our news correspondents report that additional information may be obtained by contacting Z.Q. Lin, State Food & Drug Adm, Center Drug Evaluat, Beijing 100038, People's Republic of China. Additional authors for this research include W. Gao, H.X. Hu, K. Ma, B. He, W.B. Dai, X.Q. Wang, J.C. Wang, X. Zhang and Q. Zhang (see also Polyethylene Glycols).
Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, Drugs, Beijing, Taxoids, Therapy, Alcohols, Hydrogel, Terpenes, Paclitaxel, Hydrocarbons, Cycloparaffins, Organic Chemicals, Mitotic Inhibitors, Polyethylene Glycols, People's Republic of China
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