In a new study, nanoparticles were able to cross the endothelial cell layer on the microchip under conditions that mimic the permeable layer in atherosclerosis. The results on the microfluidic device correlated well with nanoparticle accumulation in the arteries of an animal model with atherosclerosis, demonstrating the device's capability to help screen nanoparticles and optimize their design.
"It's a simple model - a microchip, not cell culture dish - which means that a simple endothelialized microchip with microelectrodes can show some yet important prediction of what's happening in a large animal model," said
The research was published in January online in the journal Proceedings of the
Kim began the work as his post-doctoral fellow at the
"This is a wonderful example of developing a novel nanotechnology approach to address an important medical problem," said
Keywords for this news article include: Blood Cells, Engineering, Nanoparticle, Nanotechnology, Atherosclerosis, Arteriosclerosis, Emerging Technologies, Cardiovascular Diseases, Arterial Occlusive Diseases,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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