News Column

Fudan University Reports Findings in Peptides and Proteins

February 18, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Peptides and Proteins is the subject of a report. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "In this work, core-shell magnetic metal organic framework (MOF) microspheres were successfully synthesized by coating magnetite particles with mercaptoacetic acid and subsequent reactions with ethanol solutions of Cu(OAc)2 and benzene-1,3,5-tricarboxylic acid (designated as H3 btc) alternately. The resulting Fe3 O4 @[Cu3 (btc)2 ] possess strong magnetic responsiveness."

Our news journalists obtained a quote from the research from Fudan University, "We applied the novel nanocomposites in the enrichment of low-concentration standard peptides, peptides in MYO and BSA tryptic digests and in human urine in combination with MALDI-TOF MS analysis for the first time. In addition, the Cu3 (btc)2 MOF shells exhibit strong affinity to peptides, thus providing a rapid and convenient approach to the concentration of low-abundance peptides. Notably, peptides at an extremely low concentration of 10 pM could be detected by MALDI-TOF MS after enrichment with the magnetic MOF composites."

According to the news editors, the research concluded: "In brief, the facile synthesis and efficient enrichment process of the Fe3 O4 @[Cu3 (btc)2 ] microspheres make them promising candidates for the isolation of peptides in even complex biological environments."

For more information on this research see: Facile synthesis of magnetic metal organic frameworks for the enrichment of low-abundance peptides for MALDI-TOF MS analysis. Proteomics, 2013;13(23-24):3387-92. (Wiley-Blackwell - www.wiley.com/; Proteomics - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1615-9861)

The news correspondents report that additional information may be obtained from M. Zhao, Dept. of Chemistry, Fudan University, Shanghai, People's Taiwan. Additional authors for this research include C. Deng, X. Zhang and P. Yang (see also Peptides and Proteins).

Keywords for this news article include: Asia, Shanghai, Proteomics, Amino Acids, Peptides and Proteins, People's Republic of China.

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Source: Life Science Weekly


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