By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Stem Cell Research are discussed in a new report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "In this study, we investigated the possibility of using local administration of allogeneic bone marrow mesenchymal stem cells (BMMSCs) to induce tissue regeneration in periodontal defects in a rat model of periodontitis. BMMSCs isolated from rats were mixed with 0.9% NaCl solution and injected into periodontal defects."
The news correspondents obtained a quote from the research from Capital Medical University, "Control groups were 0.9% NaCl solution or left untreated. The clinical assessments, x-rays, and histological examinations were used to evaluate the effect. At 12 wks post-transplantation, quantitative analysis revealed average probing bone loss values of 1.2 +/- 0.19, 1.6 +/- 0.2, and 1.7 +/- 0.14; the bone regeneration rate was 53%, 45%, and 44% in the BMMSC+NaCl group, NaCl group, and untreated group, respectively. The clinical assessments, x-rays, and histological examinations revealed significant periodontal tissue regeneration in the BMMSC injection group, compared with the control groups. The ELISA results showed that TNF, IFN, and IL1 were 2,674.88 +/- 102.77 pg/mL vs. 3,422.1 +/- 51.98 pg/mL, 609.85 +/- 25.5 pg/mL vs. 803.79 +/- 33.85 pg/mL, and 1,038.46 +/- 76.29 pg/mL vs. 1,175.26 +/- 105.55 pg/mL in the BMMSC+NaCl group and NaCl group, respectively, indicating that BMMSC injection inhibited the inflammatory factors TNF, IFN, and IL1."
According to the news reporters, the research concluded: "Our results indicate that local administration of BMMSCs can repair defects due to periodontitis, exerting anti-inflammatory and immunomodulatory functions."
For more information on this research see: Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation for Periodontal Regeneration. Journal of Dental Research, 2014;93(2):183-188. Journal of Dental Research can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA. (Sage Publications - www.sagepub.com/; Journal of Dental Research - jdr.sagepub.com)
Our news journalists report that additional information may be obtained by contacting J. Du, Capital Med Univ, Sch Basic Med Sci, Dept. of Biochem & Mol Biol, Beijing 100050, People's Republic of China. Additional authors for this research include Z. Shan, P. Ma, S. Wang and Z. Fan (see also Stem Cell Research).
Keywords for this news article include: Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Beijing, Surgery, Bone Marrow, Bone Research, Immune System, Bioengineering, Bone Regeneration, Stem Cell Research, Tissue Regeneration, Regeneration Medicine, People's Republic of China, Mesenchymal Stem Cell Transplantation
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