By a News Reporter-Staff News Editor at Stem Cell Week -- Fresh data on Stem Cell Research are presented in a new report. According to news reporting originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "Stem cell transplantation therapy has emerged as a promising regenerative medicine for ischemic stroke and other neurodegenerative disorders. However, many issues and problems remain to be resolved before successful clinical applications of the cell-based therapy."
Our news editors obtained a quote from the research from the Emory University School of Medicine, "To this end, some recent investigations have sought to benefit from well-known mechanisms of ischemic/hypoxic preconditioning. Ischemic/hypoxic preconditioning activates endogenous defense mechanisms that show marked protective effects against multiple insults found in ischemic stroke and other acute attacks. As in many other cell types, a sub-lethal hypoxic exposure significantly increases the tolerance and regenerative properties of stem cells and progenitor cells. So far, a variety of preconditioning triggers have been tested on different stem cells and progenitor cells. Preconditioned stem cells and progenitors generally show much better cell survival, increased neuronal differentiation, enhanced paracrine effects leading to increased trophic support, and improved homing to the lesion site. Transplantation of preconditioned cells helps to suppress inflammatory factors and immune responses, and promote functional recovery. Although the preconditioning strategy in stem cell therapy is still an emerging research area, accumulating information from reports over the last few years already indicates it as an attractive, if not essential, prerequisite for transplanted cells. It is expected that stem cell preconditioning and its clinical applications will attract more attention in both the basic research field of preconditioning as well as in the field of stem cell translational research."
According to the news editors, the research concluded: "This review summarizes the most important findings in this active research area, covering the preconditioning triggers, potential mechanisms, mediators, and functional benefits for stem cell transplant therapy."
For more information on this research see: Preconditioning strategy in stem cell transplantation therapy. Translational Stroke Research, 2013;4(1):76-88. (Springer - www.springer.com; Translational Stroke Research - www.springerlink.com/content/1868-4483/)
The news editors report that additional information may be obtained by contacting S.P. Yu, Dept. of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, United States. Additional authors for this research include Z. Wei and L. Wei (see also Stem Cell Research).
Keywords for this news article include: Biomedical Engineering, Biomedicine, Atlanta, Georgia, Therapy, United States, Bioengineering, Stem Cell Research, Regenerative Medicine, North and Central America.
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