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Findings in the Area of Chemical Engineering Reported from New Jersey Institute of Technology

February 19, 2014

By a News Reporter-Staff News Editor at Journal of Engineering -- Data detailed on Chemical Engineering have been presented. According to news reporting from Newark, New Jersey, by VerticalNews journalists, research stated, "Concentrated fenofibrate (FNB) nanoparticle suspensions are produced via an oil/water melt emulsification process from the micronized drug particles dispersed in water above the drug melting point. Sonication energy enables forming nanosized melt droplets, and nanosized solid particles upon subsequent cooling."

The news correspondents obtained a quote from the research from the New Jersey Institute of Technology, "Stabilization achieved via surface-active molecules is necessary to prevent coalescence of the droplets or agglomeration of the solid nanoparticles. Judicious selection of stabilizer and concentration resulted in 150-nm drug particles with solid loading up to 30%. The hydrophilic-lipophilic-balance concept is applicable, facilitating selection of surfactants based on their chemical structure."

According to the news reporters, the research concluded: "The strong in vitro dissolution rate enhancement suggests improved FNB bioavailability."

For more information on this research see: Concentrated Fenofibrate Nanoparticle Suspensions from Melt Emulsification for Enhanced Drug Dissolution. Chemical Engineering & Technology, 2014;37(1):157-167. Chemical Engineering & Technology can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Chemical Engineering & Technology -

Our news journalists report that additional information may be obtained by contacting C. Knieke, New Jersey Inst Technol, Otto H York Dept. of Chem Biol & Pharmaceut Engn, Newark, NJ 07102, United States. Additional authors for this research include A. Rawtani and R.N. Dave.

Keywords for this news article include: Newark, New Jersey, United States, Chemical Engineering, North and Central America

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Source: Journal of Engineering

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