By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Nanoparticles have been published. According to news reporting originating in Guangzhou, People's Republic of China, by NewsRx journalists, research stated, "Here we reported the high tumor targeting efficacy of luminescent Ru(II)-thiols protected selenium nanoparticles (Ru-MUA@Se). We have shown that a dual-target inhibitor Ru-MUA@Se directly suppress the tumor growth but also block blood-vessel growth."
The news reporters obtained a quote from the research from the University of Jinan, "We also determined that the nanoparticles entered the cells via clathrin-mediated endocytosis pathway. In a xenograft HepG2 tumor model, we found that Ru-MUA@Se effectively inhibited tumor angiogenesis and suppressed tumor growth with low side effects using metronomic chemotherapy with Ru-MUA@Se. In vivo investigation of nanoparticles on nude mice bearing HepG2 cancer xenografts confirmed that Ru-MUA@Se nanoparticles possessed high tumor-targeted fluorescence imaging, exhibited enhanced antitumor efficacy and decreased systemic toxicity. Moreover, Ru-MUA@Se not only significantly induced dose-dependent disruption of mitochondrial membrane potential in HepG2 cells after 24 h treatment, but it also enhanced reactive oxygen species (ROS) generation."
According to the news reporters, the research concluded: "Our results suggest that the potential application of these Ru-MUA@Se nanoparticles in targeting cancer imaging and chemotherapy."
For more information on this research see: Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles. Biomaterials, 2014;35(5):1572-83. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting D. Sun, Dept. of Chemistry, Jinan University, Guangzhou 510632, People's Taiwan. Additional authors for this research include Y. Liu, Q. Yu, X. Qin, L. Yang, Y. Zhou, L. Chen and J. Liu (see also Nanoparticles).
Keywords for this news article include: Asia, Drugs, Guangzhou, Ruthenium, Chemotherapy, Nanotechnology, Transition Elements, Emerging Technologies, People's Republic of China.
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