News Column

Findings from University of Bern in Bone Research Reported

February 17, 2014

By a News Reporter-Staff News Editor at Biotech Business Week -- Researchers detail new data in Bone Research. According to news reporting out of Bern, Switzerland, by NewsRx editors, research stated, "The application of an enamel matrix derivative (EMD) for regenerative periodontal surgery has been shown to promote formation of new cementum, periodontal ligament, and alveolar bone. In intrabony defects with a complicated anatomy, the combination of EMD with various bone grafting materials has resulted in additional clinical improvements, but the initial cellular response of osteoblasts coming in contact with these particles have not yet been fully elucidated."

Our news journalists obtained a quote from the research from the University of Bern, "The objective of the present study was to evaluate the in vitro effects of EMD combined with a natural bone mineral (NBM) on a wide variety of genes, cytokines, and transcription factors and extracellular matrix proteins on primary human osteoblasts. Primary human osteoblasts were seeded on NBM particles pre-coated with versus without EMD and analyzed for gene differences using a human osteogenesis gene super-array (Applied Biosystems). Osteoblast-related genes include those transcribed during bone mineralization, ossification, bone metabolism, cell growth and differentiation, as well as gene products representing extracellular matrix molecules, transcription factors, and cell adhesion molecules. EMD promoted gene expression of various osteoblast differentiation markers including a number of collagen types and isoforms, SMAD intracellular proteins, osteopontin, cadherin, alkaline phosphatase, and bone sialoprotein. EMD also upregulated a variety of growth factors including bone morphogenetic proteins, vascular endothelial growth factors, insulin-like growth factor, transforming growth factor, and their associated receptor proteins. The results from the present study demonstrate that EMD is capable of activating a wide variety of genes, growth factors, and cytokines when pre-coated onto NBM particles."

According to the news editors, the research concluded: "The described in vitro effects of EMD on human primary osteoblasts provide further biologic support for the clinical application of a combination of EMD with NBM particles in periodontal and oral regenerative surgery."

For more information on this research see: Gene array of primary human osteoblasts exposed to enamel matrix derivative in combination with a natural bone mineral. Clinical Oral Investigations, 2013;17(2):405-10. Clinical Oral Investigations can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer -; Clinical Oral Investigations -

Our news journalists report that additional information may be obtained by contacting R.J. Miron, Dept. of Periodontology, Dental School, University of Bern, Freiburgstrasse 7, 3010 Bern, Switzerland. Additional authors for this research include D.D. Bosshardt, Y. Zhang, D. Buser and A. Sculean (see also Bone Research).

Publisher contact information for the journal Clinical Oral Investigations is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Bern, Europe, Surgery, Peptides, Proteins, Switzerland, Amino Acids, Osteoblasts, Bone Research, Connective Tissue Cells.

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Source: Biotech Business Week

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