By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- New research on Biotechnology is the subject of a report. According to news reporting originating from Chengdu, People's Republic of China, by NewsRx correspondents, research stated, "Beta-defensins, small antimicrobial peptides, are involved in host immune responses to tumors. In this study, we used beta-defensin 2 (BD2) to explore the possible role of beta-defensins in cancer gene therapy."
Our news editors obtained a quote from the research from Sichuan University, "A recombinant plasmid expressing a secretable form of BD2 was constructed. The biological activities of BD2 in immature dendritic cells (iDCs) were tested in vitro and in vivo. The antitumor effects were investigated in three established tumor models. The secreted BD2 was detected and exhibited chemotactic activity in iDCs both in vitro and in vivo. Recruitment and activation of iDCs in tumor niches resulted in significant tumor growth inhibition. Adoptive transfer of splenocytes and depletion of immune cell subsets revealed that CD8(+) T lymphocyte responses mediated the increased tumor inhibition. Furthermore, we also found that chemotactic and maturation-inducing activities in iDCs in tumor milieu contributed to enhanced local antitumor effects. Our study indicates that gene therapy with BD2 can mediate specific antitumor immunity and augment local antitumor effects."
According to the news editors, the research concluded: "Our study also suggested that beta-defensins may merit further exploration for cancer immunotherapy as promising immunogenes."
For more information on this research see: Gene Therapy with Beta-Defensin 2 Induces Antitumor Immunity and Enhances Local Antitumor Effects. Human Gene Therapy, 2014;25(1):63-72. Human Gene Therapy can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Human Gene Therapy - www.liebertpub.com/overview/human-gene-therapy-and-part-b-methods/19/)
The news editors report that additional information may be obtained by contacting D. Li, Sichuan University, Dept. of Thorac Oncol, Center Canc, State Key Lab BiotherapyWest China Hosp, Chengdu 610042, People's Republic of China. Additional authors for this research include W. Wang, H.S. Shi, Y.J. Fu, X. Chen, X.C. Chen, Y.T. Liu, B. Kan and Y.S. Wang (see also Biotechnology).
Keywords for this news article include: Asia, Antimicrobial Cationic Peptides, Biotechnology, Chengdu, Immunotherapy, Bioengineering, beta-Defensins, Immunomodulation, Membrane Proteins, Cancer Gene Therapy, People's Republic of China, Pore Forming Cytotoxic Proteins
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