By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Essential Amino Acids is now available. According to news reporting from Chengdu, People's Republic of China, by NewsRx journalists, research stated, "It is critically important to accurately determine histidine since it is an indicator for many diseases when at an abnormal level. Here, an inexpensive and simple method using an amine-functionalized magnetic nanoparticle-based Ni2+-histidine affinity pair system was developed for highly sensitive and selective detection of histidine in human urine by photochemical vapor generation atomic spectrometry."
The news correspondents obtained a quote from the research from Sichuan University, "Ni2+ was first bound to the amine groups of the amine-functionalized magnetic nanoparticles and then liberated to solution via the highly specific interaction between the histidine and Ni2+ in the presence of histidine. The liberated histidine Ni2+ complex was exposed to UV irradiation in the presence of formic acid to form gaseous nickel tetracarbonyl, which was separated from the sample matrix and determined by atomic absorption/fluorescence spectrometry. Compared to other methods, this approach promises high sensitivity, simplicity in design, and convenient operation. The need for organic solvents, enzymatic reactions; separation processes, chemical modification, expensive instrumentations, and sophisticated and complicated pretreatment is minimized with this strategy. A limit of detection of 1 nM was obtained and provided tens-to-hundreds of fold improvements over that achieved with conventional methods."
According to the news reporters, the research concluded: "The protocol was evaluated by analysis of several urine samples with good recoveries and showed great potential for practical application."
For more information on this research see: Recyclable Decoration of Amine-Functionalized Magnetic Nanoparticles with Ni2+ for Determination of Histidine by Photochemical Vapor Generation Atomic Spectrometry. Analytical Chemistry, 2014;86(1):842-848. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)
Our news journalists report that additional information may be obtained by contacting Y. Hu, Sichuan University, Analyt & Testing Center, Chengdu 610064, Sichuan, People's Republic of China. Additional authors for this research include Q. Wang, C.B. Zheng, L. Wu, X.D. Hou and Y. Lv (see also Essential Amino Acids).
Keywords for this news article include: Asia, Chengdu, Histidine, Nanotechnology, Cyclic Amino Acids, Emerging Technologies, Essential Amino Acids, Magnetic Nanoparticles, People's Republic of China
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