News Column

Findings from A. Pottier and Co-Authors Reveals New Information on Cancer Gene Therapy

February 17, 2014

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news originating from Paris, France, by NewsRx correspondents, research stated, "Since the discovery of cisplatin about 40 years ago, the design of innovative metal-based anticancer drugs is a growing area of research. Transition metal coordination complexes offer potential advantages over the more common organic-based drugs, including a wide range of coordination number and geometries, accessible redox states, tunability of the thermodynamics and kinetics of ligand substitution, as well as a wide structural diversity."

Our news journalists obtained a quote from the research, "Metal-based substances interact with cell molecular targets, affecting biochemical functions resulting in cancer cell destruction. Radionuclides are another way to use metals as anticancer therapy. The metal nucleus of the unstable radionuclide becomes stable by emitting energy. The biological effect in different tissues is obtained by the absorption of this energy from the radiation emitted by the radionuclide, the principal target generally agreed for ionizing radiations being DNA. A new area of clinical research is now emerging using the same experimental metal elements, but in a radically different manner: metals and metal oxides used as crystalline nanosized particles. In this field, man-made functionalized nanoparticles of high electron density and well-defined size and shape offer the possibility of entering cancer cells and depositing high amounts of energy in the tumor only when exposed to ionizing radiations (on/off activity). These nanoparticles, such as hafnium oxide engineered as 50 nm-sized spheres, functionalized with a negative surface (NBTXR3 nanoparticles), have been developed as selective radioenhancers, which represents a breakthrough approach for the local treatment of solid tumors. The properties of NBTXR3 nanoparticles, their chemistry, size, shape and surface charge, have been designed for efficient tumor cell uptake. NBTXR3 brings a physical mode of action, that of radiotherapy, within the cancer cells themselves. Physicochemical characteristics of NBTXR3 have demonstrated a very promising benefit-risk ratio for human healthcare across a broad non-clinical program."

According to the news editors, the research concluded: "NBTXR3 has entered clinical development in therapy of advanced soft tissue sarcomas and head and neck cancer."

For more information on this research see: New Use of Metals as Nanosized Radioenhancers. Anticancer Research, 2014;34(1B):443-453. Anticancer Research can be contacted at: Int Inst Anticancer Research, Editorial Office 1ST Km Kapandritiou-Kalamou Rd Kapandriti, PO Box 22, Athens 19014, Greece. (International Institute of Anticancer Research -; Anticancer Research -

The news correspondents report that additional information may be obtained from A. Pottier, Nanobiotix, F-75012 Paris, France. Additional authors for this research include E. Borghi and L. Levy (see also Biotechnology).

Keywords for this news article include: Biotechnology, Paris, France, Europe, Oncology, Nanoparticle, Radiotherapy, Nanotechnology, Cancer Gene Therapy, Emerging Technologies

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Source: Cancer Gene Therapy Week

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