The news correspondents obtained a quote from the research, "Among them, two aptamers (TGA6 and TGA7) with the highest affinities are employed as capture probe and detection probe in developing a quantum dots-labeled dual aptasensor (Q-DAS). In the presence of antitoxoplasma IgG, an aptamer-protein-aptamer sandwich complex (TGA6-IgG-TGA7) is formed and captured on a multiwell microplate, whose fluorescence can be read out using quantum dots as the fluorescence label, ensuring highly sensitive and specific sensing of antitoxoplasma IgG. The operating characteristics of the proposed assay are guaranteed using dual aptamers as the recognizing probes when compared with antibody-based immunoassay. Q-DAS has a linearity within the range of 0.5-500 IU with a lowest detection of 0.1 IU."
According to the news reporters, the research concluded: "Receiver operating curves of 212 clinical samples show a 94.8% sensitivity and 95.7% specificity when the cutoff value is set as 6.5 IU, indicating the proposed Q-DAS is a promising assay in large-scale screening of toxoplasmosis."
For more information on this research see: Dual-Aptamer-Based Biosensing of Toxoplasma Antibody. Analytical Chemistry, 2013;85(17):8354-8360. Analytical Chemistry can be contacted at: Amer Chemical Soc,
Our news journalists report that additional information may be obtained by contacting Y. Luo, Clin Lab Center Chongqing,
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