By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Extracellular Space are presented in a new report. According to news reporting out of Rehovot, Israel, by NewsRx editors, research stated, "Cancer cells rely on extensive support from the stroma in order to survive, proliferate and invade. The tumor stroma is thus an important potential target for anti-cancer therapy."
Our news journalists obtained a quote from the research from the Weizmann Institute of Science, "Typical changes in the stroma include a shift from the quiescence promoting-antiangiogenic extracellular matrix to a provisional matrix that promotes invasion and angiogenesis. These changes in the extracellular matrix are induced by changes in the secretion of extracellular matrix proteins and glucose amino glycans, extravasation of plasma proteins from hyperpermeable vessels and release of matrix modifying enzymes resulting in cleavage and cross-linking of matrix macromolecules. These in turn alter the rigidity of the matrix and the exposure and release of cytokines. Changes in matrix rigidity and vessel permeability affect drug delivery and mediate resistance to cytotoxic therapy. These stroma changes are brought about not only by the cancer cells, but also through the action of many cell types that are recruited by tumors including immune cells, fibroblasts and endothelial cells. Within the tumor, these normal host cells are activated resulting in loss of inhibitory and induction of cancer promoting activities."
According to the news editors, the research concluded: "Key to the development of stroma-targeted therapies, selective biomarkers were developed for specific imaging of key aspects of the tumor stroma."
For more information on this research see: Imaging aspects of the tumor stroma with therapeutic implications. Pharmacology & Therapeutics, 2014;141(2):192-208. Pharmacology & Therapeutics can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Pharmacology & Therapeutics - www.elsevier.com/wps/product/cws_home/525486)
Our news journalists report that additional information may be obtained by contacting L. Narunsky, Weizmann Inst Sci, Dept. of Regulat Biol, IL-76100 Rehovot, Israel. Additional authors for this research include R. Oren, F. Bochner and M. Neeman (see also Extracellular Space).
Keywords for this news article include: Asia, Israel, Cancer, Rehovot, Therapy, Oncology, Extracellular Space, Extracellular Matrix
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