By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting originating from Kwangju, South Korea, by NewsRx correspondents, research stated, "Chronic tympanic membrane ™ perforation is one of the most common otology complications. Current surgical management of TM perforation includes myringoplasty and tympanoplasty."
Our news editors obtained a quote from the research from the Gwangju Institute of Science and Technology (GIST), "The purpose of this study was to evaluate the efficacy and feasibility of three dimensional (3D) porous collagen scaffolds with topically applied human umbilical cord serum (UCS) for the regeneration of chronic TM perforation in guinea pigs. To achieve this goal, we fabricated porous 3D collagen scaffolds (avg. strut diameter of 236 +/- 51 mu m, avg. pore size of 382 +/- 67 mu m, and a porosity of 96%) by using a 3 axis robot dispensing and low temperature plate systems. Guinea pigs were used in a model of chronic TM perforation. In the experimental group (n = 10), 3D collagen scaffold was placed on the perforation and topically applied of UCS every other day for a period of 8 days. The control group ears (n = 10) were treated with paper discs and phosphate buffered saline (PBS) only using the same regimen. Healing time, acoustic-mechanical properties, and morphological analysis were performed by otoendoscopy, auditory brainstem response (ABR), single-point laser Doppler vibrometer (LDV), optical coherence tomography (OCT), and light microscopic evaluation. The closure of the TM perforation was achieved in 100% of the experimental group vs. 43% of the control group, and this difference was statistically significant (p = 0.034). The ABR threshold at all frequencies of the experimental group was significantly recovered to the normal level compared to the control group. TM vibration velocity in the experimental group recovered similar to the normal control level. The difference is very small and they are not statistically significant below 1 kHz (p = 0.074). By OCT and light microscopic examination, regenerated TM of the experimental group showed thickened fibrous and mucosal layer."
According to the news editors, the research concluded: "In contrast, the control group showed absence of fibrous layer like a dimeric TM."
For more information on this research see: Regeneration of chronic tympanic membrane perforation using 3D collagen with topical umbilical cord serum. International Journal of Biological Macromolecules, 2013;62():232-240. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
The news editors report that additional information may be obtained by contacting C.H. Jang, Gwangju Inst Sci & Technol, Sch Informat & Commun, Kwangju, South Korea. Additional authors for this research include Y.B. Cho, M. Yeo, H. Lee, E.J. Min, B.H. Lee and G.H. Kim (see also Proteins).
Keywords for this news article include: Asia, Kwangju, Collagen, South Korea, Extracellular Matrix Proteins
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC