Genetic systems run like clockwork, attuned to temperature, time of day and many other factors as they regulate living organisms. Scientists at
Until now, synthetic biologists have not been able to duplicate this marvel, but
The revelation will be of interest to biologists who study regulatory systems, particularly circadian rhythms, but it may be most valuable to synthetic biologists who wish to reprogram cellular regulatory mechanisms for biotechnology, Bennett said.
"One of the problems we've had is that the genetic circuits we build are fragile," he said. "We can build systems that do what we want, but they often do not work well in other people's hands, or if we change the media or temperature. We wanted to create a system that should work independently of the parameters that might be hard for a synthetic biologist to control. We want to show we can build robust circuits, not just by making the architecture of the system more complicated, but by using the right proteins."
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