Specific Technologies, developer of rapid identification systems for disease causing pathogens, said that a study published online in the In a release, the Company noted:
In the study,
Sepsis is the 10th leading cause of death, killing more than prostate cancer, breast cancer, and HIV/AIDS combined, and is responsible for 11 percent of intensive care unit admissions with a mortality rate estimated at 28 to 50 percent.
In the study, the authors compared the SpecID system to the bioMerieux BacT/ALERT system, and reported that the SpecID system identified bacterial species in blood culture 22 percent faster on average than the BacT/ALERT system, which simply reported presence of the infection. Further, the metabolomic "fingerprint" obtained by the sensor enabled discrimination of distinct strains comparable to that achieved by pulsed gel electrophoretic methods. The SpecID system thus combines earlier detection with the characterization of species in a single, fully automated step. This contrasts with all other systems in current use in which characterization of the specific bacteria species requires a second step, additional sample preparation, contamination risk, and expense.
"These significant results present a new paradigm for time- sensitive bacteria identification," said Dr.
The study was supported in part by a
The manuscript, "Colorimetric Sensor Array Allows Earlier Detection and Simultaneous Identification of Sepsis-Causing Bacteria in Spiked Blood Culture" can be found online at http://jcm.asm.org/ content/early/2013/12/05/JCM.02377-13.abstract?sid=89c688ac-67fe- 457e-ad0e-3e31c3b076e1.
During growth in culture, bacteria produce small molecule volatile metabolites unique to their species and strain. Specific Technologies has developed the SpecID system, a new paradigm for identifying microorganisms from the metabolomic signature of organism outgas into culture headspace.
Utilizing a chemical fingerprint that combines detection and identification into a simple, automated single step utilizing a low- cost disposable printed sensory array, the SpecID system delivers both detection and species identification results in one simultaneous step, both less expensively and well before molecular and mass spectrometry (MALDI-TOF) methods.
The paper also demonstrated that the SpecID fingerprint discriminates between even highly similar strains of Staphylococcus aureus, indicating that the metabolomic fingerprint is not just species specific but strain-specific as well. The SpecID system requires no additional instruments, no additional labor, and no new process steps.
Specific Technologies has developed in vitro systems for rapid identification of cells, and is applying this fundamental new platform to the detection and characterization of microorganisms causing blood infection.
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Specific Technologies, developer of rapid identification systems for disease causing pathogens, said that a study published online in the
In a release, the Company noted: