By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Proteins. According to news reporting originating in Baltimore, Maryland, by NewsRx journalists, research stated, "The protective barrier, lubricant, and clearance functions of mucus are intimately coupled to its microstructure and bulk rheology. Mucus gels consist of a network of mucin biopolymers along with lipids, salts, and other proteins and exhibit similar biochemical and physical properties across diverse mucosal surfaces."
The news reporters obtained a quote from the research from Johns Hopkins University, "Nevertheless, mucus is exposed to a broad range of pH values throughout the human body. Protein functions are typically sensitive to small changes in pH, and prior investigations using reconstituted, purified mucin gels suggested mucus undergoes a transition from a low-viscosity liquid at neutral pH to a highly viscoelastic solid at low pH. We sought to determine whether those observations hold for fresh, minimally perturbed human mucus ex vivo by using different-sized muco-inert nanoparticles to probe microstructure and cone-and-plate rheometry to measure bulk rheology. We demonstrate that both the microstructure and bulk rheology of fresh, undiluted, and minimally perturbed cervicovaginal mucus exhibit relatively minor changes from pH 1-2 to 8-9, in marked contrast with the pH sensitivity of purified mucin gels."
According to the news reporters, the research concluded: "Our work also suggests additional components in mucus secretions, typically eliminated during mucin purification and reconstitution, may play an important role in maintaining the protective properties of mucus."
For more information on this research see: The Microstructure and Bulk Rheology of Human Cervicovaginal Mucus Are Remarkably Resistant to Changes in pH. Biomacromolecules, 2013;14(12):4429-4435. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)
Our news correspondents report that additional information may be obtained by contacting Y.Y. Wang, Johns Hopkins University, Center Canc Nanotechnol Excellence, Inst NanoBioTechnol, Baltimore, MD 21218, United States. Additional authors for this research include S.K. Lai, L.M. Ensign, W.X. Zhong, R. Cone and J. Hanes (see also Proteins).
Keywords for this news article include: Mucins, Maryland, Baltimore, Mucoproteins, United States, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC